Thermo Fisher Scientific FGFR1 Monoclonal Antibody (M2F12)
FGFR1 단백질을 특이적으로 인식하는 Thermo Fisher Scientific의 단클론 항체(M2F12). Western blot, IHC, Flow Cytometry 등 다양한 응용에 적합. 인간, 생쥐, 랫드 시료에 반응하며, Protein G로 정제된 고순도 항체. 연구용으로만 사용.
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Applications and Tested Dilution
| Application | Tested Dilution | Publications |
|---|---|---|
| Western Blot (WB) | 1 µg/mL | View 1 publication |
| Immunohistochemistry (Paraffin) (IHC (P)) | Assay-dependent | - |
| Immunohistochemistry (Frozen) (IHC (F)) | Assay-dependent | - |
| Immunocytochemistry (ICC/IF) | - | View 1 publication |
| Flow Cytometry (Flow) | Assay-dependent | - |
| Immunoprecipitation (IP) | Assay-dependent | - |
| ChIP assay (ChIP) | - | View 1 publication |
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human, Mouse, Rat |
| Published Species | Mouse |
| Host / Isotype | Mouse / IgG2a |
| Class | Monoclonal |
| Type | Antibody |
| Clone | M2F12 |
| Immunogen | Recombinant human ectodomain of FGFr1a, expressed in E. coli beginning with pro23; antigen contained NH2-terminal gly-ser-pro-gly-ile and COOH-terminal sequence |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Purification | Protein G |
| Storage Buffer | PBS, pH 7.4 |
| Contains | No preservative |
| Storage Conditions | Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles. |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
| RRID | AB_2103104 |
Product Specific Information
Store product as a concentrated solution. Centrifuge briefly prior to opening the vial.
Target Information
FGFR1 (also known as FLT2) is a member of the Fibroblast Growth Factor Receptor family (FGFR1–4), which are membrane-spanning tyrosine kinases serving as high-affinity receptors for fibroblast growth factors (FGF1–17).
These receptors play crucial roles in various biological processes such as mesoderm induction, cell growth, migration, organ formation, and bone development.
FGFR1 undergoes alternative splicing, generating multiple isoforms that are differentially expressed during embryonic and adult stages.
Mutations or aberrations in FGFR1 are associated with several disorders, including Pfeiffer syndrome, idiopathic hypogonadotropic hypogonadism (IHH), Kallmann syndrome type 2 (KAL2), osteoglophonic dysplasia (OGD), non-syndromic trigonocephaly, Jackson-Weiss syndrome, and Antley-Bixler syndrome.
Chromosomal aberrations involving FGFR1 are linked to stem cell myeloproliferative disorder and stem cell leukemia lymphoma syndrome.
For Research Use Only.
Not for use in diagnostic procedures. Not for resale without express authorization.
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