ELK Biotechnology EIF3A rabbit pAb

제품명

EIF3A rabbit pAb

공급업체

ELK Biotechnology

제품 설명

EIF3A rabbit polyclonal antibody는 eukaryotic translation initiation factor 3 (eIF-3) 복합체의 구성 요소인 EIF3A 단백질을 인식합니다. 이 복합체는 단백질 합성 개시 단계에서 중요한 역할을 하며, 40S 리보솜과 결합하여 다양한 initiation factor를 모집하고 43S preinitiation complex 형성을 촉진합니다.

제품 스펙

Background

Function: Component of the eukaryotic translation initiation factor 3 (eIF-3) complex, which is required for several steps in the initiation of protein synthesis. The eIF-3 complex associates with the 40S ribosome and facilitates the recruitment of eIF-1, eIF-1A, eIF-2:GTP:methionyl-tRNAi and eIF-5 to form the 43S preinitiation complex (43S PIC). It stimulates mRNA recruitment to the 43S PIC and scanning of the mRNA for AUG recognition.
Additional Information:

• Required for disassembly and recycling of posttermination ribosomal complexes
• Phosphorylation enhanced upon serum stimulation
• Belongs to the eIF-3 subunit A family
• Contains 1 PCI domain
• Interacts with EIF4G1 (by similarity)
• Part of the eIF-3 complex composed of 13 subunits (EIF3A–EIF3M)
• Complex modules:
  • Module A: EIF3A, EIF3B, EIF3G, EIF3I
  • Module B: EIF3F, EIF3H, EIF3M
  • Module C: EIF3C, EIF3D, EIF3E, EIF3L, EIF3K
• EIF3C binds EIF3B and EIF3H, linking modules
• EIF3J is a labile subunit binding via EIF3B
• Interacts with RPS6KB1 under nutrient depletion conditions
• Mitogenic stimulation activates FRAP1–RAPTOR complex leading to phosphorylation and EIF4B binding
• Also interacts with KRT7 and PIWIL2