Thermo Fisher Scientific Myocilin Polyclonal Antibody
Myocilin 단백질을 인식하는 Rabbit Polyclonal 항체로, Human, Mouse, Rat 등 다양한 종에 반응합니다. WB, IHC, ICC, ELISA, IP 등 다중 응용에 적합하며, Affinity chromatography로 정제되었습니다. 연구용으로만 사용 가능합니다.
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Applications and Tested Dilutions
| Application | Tested Dilution |
|---|---|
| Western Blot (WB) | 1:500–1:1,000 |
| Immunohistochemistry (IHC) | 1:50–1:250 |
| Immunocytochemistry (ICC/IF) | 1:50–1:250 |
| ELISA | 1:10,000 |
| Immunoprecipitation (IP) | 1:50–1:250 |
| Immunomicroscopy (IM) | 1:50–1:200 |
Product Specifications
| Specification | Description |
|---|---|
| Species Reactivity | Human, Mouse, Non-human primate, Rat |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | Synthetic peptide corresponding to unique amino acid sequence on Myocilin protein |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 0.5–1.5 mg/mL |
| Purification | Affinity chromatography |
| Storage Buffer | Proprietary buffer (pH 7.4–7.8) with 0.5% BSA and 30% glycerol |
| Contains | 0.02% sodium azide |
| Storage Conditions | –20°C |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
Target Information
Myocilin is an extracellular protein expressed in the eye, including the retina, trabecular meshwork, and ciliary body. It forms homomultimers in vivo and interacts with extracellular matrix components through the Hep II domain of FibroPVRL1. Myocilin also binds to the myosin regulatory light chain, suggesting a role in the actomyosin system and the regulation of trabecular meshwork (TM) function, which controls intraocular pressure (IOP). Dysfunction of TM can lead to elevated IOP and glaucoma development. The MYOC gene (also known as TIGR), located at the GLC1A locus on chromosome 1q24.3, is associated with primary open-angle glaucoma (POAG), a leading cause of blindness.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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