Thermo Fisher Scientific Myocilin Polyclonal Antibody, FITC
FITC 형광 표지된 Myocilin 폴리클로날 항체로, 인간 및 설치류 등 다양한 종에 반응합니다. Western blot, IHC, ICC, ELISA 등 다양한 응용에 적합하며, 친화 크로마토그래피로 정제된 고순도 제품입니다. 연구용으로만 사용 가능합니다.
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Applications and Tested Dilution
| Application | Tested Dilution |
|---|---|
| Western Blot (WB) | 1:500–1:1,000 |
| Immunohistochemistry (IHC) | 1:50–1:250 |
| Immunocytochemistry (ICC/IF) | 1:50–1:250 |
| ELISA | 1:10,000 |
| Immunoprecipitation (IP) | 1:50–1:250 |
| Immunomicroscopy (IM) | 1:50–1:200 |
Product Specifications
| Specification | Description |
|---|---|
| Species Reactivity | Human, Mouse, Non-human primate, Rat |
| Host/Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | Synthetic peptide corresponding to unique amino acid sequence on Myocilin protein |
| Conjugate | FITC |
| Excitation/Emission Max | 498 / 517 nm |
| Form | Liquid |
| Concentration | 0.5–1.5 mg/mL |
| Purification | Affinity chromatography |
| Storage Buffer | Proprietary buffer, pH 7.4–7.8, with 30% glycerol, 0.5% BSA |
| Contains | 0.02% sodium azide |
| Storage Conditions | -20°C, store in dark |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
Target Information
Myocilin is an extracellular protein expressed in the eye, including the retina, trabecular meshwork, and ciliary body. It can form homomultimers in vivo and associate with extracellular matrix components via interactions with the Hep II domain of FibroPVRL1. Myocilin also interacts with myosin regulatory light chain, suggesting a role in the actomyosin system and in regulating trabecular meshwork function, which controls intraocular pressure (IOP). Dysfunction of this system may lead to elevated IOP and glaucoma. The MYOC gene (also known as TIGR) is located at the GLC1A locus on chromosome 1q24.3, and mutations in this gene are linked to primary open-angle glaucoma (POAG).
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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