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Thermo Fisher Scientific Cytokeratin (HMW) Monoclonal Antibody (34bE12)
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사이토케라틴(HMW)을 인식하는 단클론 항체로, 면역조직화학(IHC) 분석에 적합합니다. 인간 시료에 반응하며, 단백질 A로 정제된 액상 형태입니다. 피부 조직에서 양성 대조로 사용 가능하며, 세포질에 위치한 케라틴 검출에 유용합니다.
- 카탈로그번호
- 605-340
- 판매단위
- pk
카탈로그
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마지막 업데이트 2025. 08. 04. 오전 06:21
카탈로그 번호 · 상품 설명출고판매가담기
Thermo Fisher Scientific 605-340 Cytokeratin (HMW) Monoclonal Antibody (34bE12) 100 ug pk판매 단위 pk ·
재고 확인 필요
421,400원VAT 포함 463,540원
Thermo Fisher Scientific · Thermo Fisher Scientific Cytokeratin (HMW) Monoclonal Antibody (34bE12)
Applications
Immunohistochemistry (Paraffin) (IHC (P))
- Tested Dilution: 2–10 µg/mL
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human |
| Host / Isotype | Mouse / IgG1 |
| Class | Monoclonal |
| Type | Antibody |
| Clone | 34bE12 |
| Immunogen | A synthetic peptide of Cytokeratin (HMW) |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 0.5 mg/mL |
| Purification | Protein A |
| Storage Buffer | PBS with proprietary stabilizer |
| Contains | 0.01% sodium azide |
| Storage Conditions | Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles. |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
Product Specific Information
- Positive control: Skin
- Cellular location: Cytoplasmic
Target Information
Keratins are heteropolymeric structural proteins forming intermediate filaments in epithelial cells. Cytokeratins are classified into two groups: low molecular weight acidic type I and high molecular weight basic type II. They typically exist as pairs of one type I and one type II keratin.
- KRT1: Regulates kinase activity (PKC, SRC) via integrin β1 and RACK1 binding; expressed in spinous and granular epidermal layers with KRT10. Mutations cause bullous congenital ichthyosiform erythroderma.
- KRT5: Expressed in basal epidermal layer with KRT14; mutations cause epidermolysis bullosa simplex.
- KRT10: Contributes to epidermal barrier formation; mediates S. aureus adherence to nasal epithelial cells. Mutations cause epidermolytic hyperkeratosis.
- KRT14: Promotes KRT5-KRT14 filament bundling, enhancing mechanical resilience; mutations cause epidermolysis bullosa simplex.
For Research Use Only.
Not for use in diagnostic procedures. Not for resale without express authorization.
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