Thermo Fisher Scientific Cytokeratin (HMW) Monoclonal Antibody (34bE12)
사이토케라틴(HMW)을 인식하는 단클론 항체로, 면역조직화학(IHC) 분석에 적합합니다. 인간 시료에 반응하며, 단백질 A로 정제된 액상 형태입니다. 피부 조직에서 양성 대조로 사용 가능하며, 세포질에 위치한 케라틴 검출에 유용합니다.
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Applications
Immunohistochemistry (Paraffin) (IHC (P))
- Tested Dilution: 2–10 µg/mL
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human |
| Host / Isotype | Mouse / IgG1 |
| Class | Monoclonal |
| Type | Antibody |
| Clone | 34bE12 |
| Immunogen | A synthetic peptide of Cytokeratin (HMW) |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 0.5 mg/mL |
| Purification | Protein A |
| Storage Buffer | PBS with proprietary stabilizer |
| Contains | 0.01% sodium azide |
| Storage Conditions | Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles. |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
Product Specific Information
- Positive control: Skin
- Cellular location: Cytoplasmic
Target Information
Keratins are heteropolymeric structural proteins forming intermediate filaments in epithelial cells. Cytokeratins are classified into two groups: low molecular weight acidic type I and high molecular weight basic type II. They typically exist as pairs of one type I and one type II keratin.
- KRT1: Regulates kinase activity (PKC, SRC) via integrin β1 and RACK1 binding; expressed in spinous and granular epidermal layers with KRT10. Mutations cause bullous congenital ichthyosiform erythroderma.
- KRT5: Expressed in basal epidermal layer with KRT14; mutations cause epidermolysis bullosa simplex.
- KRT10: Contributes to epidermal barrier formation; mediates S. aureus adherence to nasal epithelial cells. Mutations cause epidermolytic hyperkeratosis.
- KRT14: Promotes KRT5-KRT14 filament bundling, enhancing mechanical resilience; mutations cause epidermolysis bullosa simplex.
For Research Use Only.
Not for use in diagnostic procedures. Not for resale without express authorization.
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