Thermo Fisher Scientific ATP7B Polyclonal Antibody
ATP7B 단백질을 인식하는 Rabbit Polyclonal Antibody로, Western blot, IHC, ELISA에 적합합니다. Human 및 Rat 시료에 반응하며, 고순도 Affinity Chromatography 정제 제품입니다. 세포 내 구리 수송 연구 및 Wilson 병 관련 연구에 활용 가능합니다.
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Applications and Tested Dilutions
| Application | Tested Dilution |
|---|---|
| Western Blot (WB) | 1:1,000–1:2,000 |
| Immunohistochemistry (Paraffin) (IHC (P)) | 1:50–1:200 |
| ELISA | 1 µg/mL |
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human, Rat |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | Recombinant fusion protein containing a sequence corresponding to amino acids 1251–1351 of human ATP7B (NP_0012301111) |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1.73 mg/mL |
| Purification | Affinity Chromatography |
| Storage Buffer | PBS, pH 7.3, with 50% glycerol |
| Contains | 0.05% ProClin 300 |
| Storage Conditions | -20°C, Avoid Freeze/Thaw Cycles |
| Shipping Conditions | Wet ice |
| RRID | AB_2914510 |
Product Specific Information
Positive test controls include: BT-474, HL-60, Mouse liver.
The target is usually found in the following locations: Cytoplasm, Golgi apparatus, Golgi apparatus membrane, Mitochondrion, Multi-pass membrane protein, trans-Golgi network membrane.
Immunogen sequence:
SSVSVVLSSL QLKCYKKPDL ERYEAQAHGH MKPLTASQVS VHIGMDDRWR DSPRATPWDQ VSYVSQVSLS SLTSDKPSRH SAAADDDGDK WSLLLNGRDE E
Target Information
This gene belongs to the P-type cation transport ATPase family and encodes a protein with several membrane-spanning domains, an ATPase consensus sequence, a hinge domain, a phosphorylation site, and at least two putative copper-binding sites.
The protein functions as a monomer, exporting copper out of cells, such as the efflux of hepatic copper into the bile.
Alternate transcriptional splice variants encoding different isoforms with distinct cellular localizations have been characterized.
Mutations in this gene have been associated with Wilson disease (WD).
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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