Thermo Fisher Scientific Mesothelin Monoclonal Antibody (K1)
Mesothelin 단백질을 인식하는 Mouse IgG1 단클론 항체로, IHC(F), ICC/IF, ELISA 등에 사용 가능. 인간 OVCAR-3 세포 유래 면역원으로 제작. 액상 형태, 4°C 보관. 암세포에서의 Mesothelin 발현 연구에 적합.
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Applications and Tested Dilution
| Application | Tested Dilution | Publications |
|---|---|---|
| Immunohistochemistry (Frozen) (IHC (F)) | 1:40 | - |
| Immunocytochemistry (ICC/IF) | Assay-dependent | - |
| ELISA | - | View 1 publication |
Product Specifications
| Specification | Description |
|---|---|
| Published species | Not Applicable |
| Host / Isotype | Mouse / IgG1 |
| Class | Monoclonal |
| Type | Antibody |
| Clone | K1 |
| Immunogen | Spleen lymphocytes from mice fused with OVCAR-3, an ovarian tumor cell line derived from poorly differentiated adenocarcinoma of the ovary. |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 3.3 mg/mL |
| Storage conditions | 4°C |
| Shipping conditions | Wet ice |
| RRID | AB_794846 |
Product Specific Information
Recommended positive controls: Tonsil, lymph node, and OVCAR-3 cells (human).
Target Information
Mesothelin was originally identified as a differentiation antigen of mesotheliomas, ovarian cystadenocarcinomas, and pancreatic adenocarcinomas. It is a glycosylphosphatidylinositol (GPI)-anchored, cell-surface glycoprotein predominantly secreted by mesothelial cells.
While normally expressed at restricted levels in pleural, pericardial, and peritoneal membranes, aberrant expression is observed in various cancers including endometrioid uterine adenocarcinomas and squamous cell carcinomas of the esophagus, stomach, lung, and cervix.
Proteolytic cleavage of Mesothelin produces a soluble fragment called megakaryocyte potentiating factor (MPF), which stimulates megakaryocyte colony formation and may regulate platelet production.
Both Mesothelin and MPF are implicated in tumorigenesis, promoting tumor cell proliferation, migration, anchorage-independent growth, and metastatic progression.
For Research Use Only.
Not for use in diagnostic procedures.
Not for resale without express authorization.
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