Thermo Fisher Scientific Blood Group Lewis Y Monoclonal Antibody (F3)

Applications

Tested Dilution

Publications

Western Blot (WB)

Assay-dependent

-

Immunohistochemistry (Paraffin) (IHC (P))

1:40

-

Flow Cytometry (Flow)

Assay-dependent

-

Product Specifications

Host/Isotype

Mouse / IgM

Class

Monoclonal

Type

Antibody

Clone

F3

Immunogen

SK-LU-3 human lung cancer cell line.

Conjugate

Unconjugated Unconjugated Unconjugated

Form

Liquid

Storage conditions

4° C

Shipping conditions

Wet ice

RRID

AB_794771

Product Specific Information

MA1-26525 detects Blood Group Lewis Y from human samples.

MA1-26525 has been successfully used in immunohistochemistry (paraffin), Flow cytometry, and Western blot procedures.

The MA1-26525 immunogen is SK-LU-3 human lung cancer cell line.

Target Information

The Lewis histo-blood group system comprises a set of fucosylated glycosphingolipids that are synthesized by exocrine epithelial cells and circulate in body fluids. The glycosphingolipids function in embryogenesis, tissue differentiation, tumor metastasis, inflammation, and bacterial adhesion. They are secondarily absorbed to red blood cells giving rise to their Lewis phenotype. This gene is a member of the fucosyltransferase family, which catalyzes the addition of fucose to precursor polysaccharides in the last step of Lewis antigen biosynthesis. It encodes an enzyme with alpha(1,3)-fucosyltransferase and alpha(1,4)-fucosyltransferase activities. Mutations in this gene are responsible for the majority of Lewis antigen-negative phenotypes. Multiple alternatively spliced variants, encoding the same protein, have been found for this gene.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.