Thermo Fisher Scientific Blood Group Lewis Y Monoclonal Antibody (F3)

Thermo Fisher Scientific Blood Group Lewis Y Monoclonal Antibody (F3)

Applications

Product Specifications

Product Specific Information

MA1-26525 detects Blood Group Lewis Y from human samples.
It has been successfully used in immunohistochemistry (paraffin), flow cytometry, and western blot procedures.
The immunogen used for MA1-26525 is the SK-LU-3 human lung cancer cell line.

Target Information

The Lewis histo-blood group system comprises a set of fucosylated glycosphingolipids synthesized by exocrine epithelial cells and circulating in body fluids.
These glycosphingolipids are involved in embryogenesis, tissue differentiation, tumor metastasis, inflammation, and bacterial adhesion.
They are secondarily absorbed to red blood cells, giving rise to their Lewis phenotype.
The gene encoding this system belongs to the fucosyltransferase family, catalyzing the addition of fucose to precursor polysaccharides during the final step of Lewis antigen biosynthesis.
Mutations in this gene cause Lewis antigen-negative phenotypes. Multiple alternatively spliced variants encoding the same protein have been identified.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.