Thermo Fisher Scientific Huntingtin Recombinant Superclonal Antibody (3HCLC)

Applications

Immunocytochemistry (ICC/IF)

• Tested Dilution: 2 µg/mL

Product Specifications

Product Specific Information

• Predicted to react with Monkey, Mouse, and Bovine.
• Recombinant rabbit Superclonal™ antibodies combine multiple recombinant monoclonal antibodies, offering polyclonal sensitivity with monoclonal specificity and recombinant consistency.
• Each lot is produced with a known mixture of light and heavy chains, avoiding biological variability of polyclonal antibodies.
• Formerly called “Recombinant polyclonal antibody”, now rebranded as “Recombinant Superclonal™ antibody”.
• Physical product and performance remain unchanged.

Target Information

Huntingtin is a disease gene linked to Huntington’s disease (HD), a neurodegenerative disorder characterized by loss of striatal neurons. The disorder is caused by an expanded, unstable trinucleotide repeat in the huntingtin gene, which translates as a polyglutamine repeat in the protein product.
HD is a mid-life onset autosomal dominant neurodegenerative disease characterized by psychiatric disorders, dementia, and involuntary movements (chorea), leading to death in 10–20 years.
The huntingtin locus spans 180 kb and consists of 67 exons. It is widely expressed and required for normal development, with two alternatively polyadenylated forms showing different abundance in fetal and adult tissues.
The larger transcript (~13.7 kb) is mainly expressed in brain, while the smaller (~10.3 kb) is more broadly expressed.
The genetic defect may not eliminate transcription but can alter mRNA or protein function.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.

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