Thermo Fisher Scientific Perforin-1 (Pore Forming Protein) (Apoptosis Marker) Monoclonal Antibody (PRF1/2470)

Applications and Tested Dilution

Product Specifications

Target Information

Perforin is one of the major cytolytic proteins of cytolytic granules. It acts as a cytolytic mediator stored in and released by cytoplasmic granules and plays a crucial role in immune defense against tumors and viral infections mediated by cytotoxic lymphocytes.
Perforin is a 555 amino acid protein with a 21 amino acid signal peptide and a molecular weight of approximately 70–75 kDa. It forms transmembrane channels similar to complement component C9, sharing structural homology.
Expression of perforin is restricted to killer cell lines and is absent in helper T lymphocytes and other tumor cells. It is a key effector molecule for T-cell and NK-cell-mediated cytolysis. Mutations in the perforin gene cause familial hemophagocytic lymphohistiocytosis type 2 (HPLH2), a rare and lethal autosomal recessive disorder in early childhood. Alternative splicing produces multiple transcript variants.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.