Thermo Fisher Scientific Perforin-1 (Pore Forming Protein) (Apoptosis Marker) Monoclonal Antibody (PRF1/2470)
인간 Perforin-1 단백질을 표적으로 하는 단클론 항체로, 세포독성 림프구의 세포사멸 표지 연구에 적합. IHC(P), IHC(PFA), Peptide Array 등 다양한 응용 가능. Protein A/G 정제, PBS 버퍼 내 보존. 연구용으로만 사용.
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Applications and Tested Dilution
| Application | Tested Dilution |
|---|---|
| Immunohistochemistry (Paraffin) (IHC (P)) | Assay-dependent |
| Immunohistochemistry (PFA fixed) (IHC (PFA)) | 1–2 µg/mL |
| Peptide Array (Array) | Assay-dependent |
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human |
| Host / Isotype | Mouse / IgG2c, kappa |
| Class | Monoclonal |
| Type | Antibody |
| Clone | PRF1/2470 |
| Immunogen | Recombinant human Perforin-1 protein fragment (around aa 413–552) |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 200 µg/mL |
| Purification | Protein A/G |
| Storage Buffer | PBS, pH 7.4, with 0.05% BSA |
| Contains | 0.05% sodium azide |
| Storage Conditions | 4°C, do not freeze |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
Target Information
Perforin is one of the major cytolytic proteins found in cytolytic granules. It acts as a pore-forming protein involved in immune defense against tumors and viral infections, mediated by cytotoxic lymphocytes. The protein consists of 555 amino acids, including a 21 amino acid signal peptide, with a molecular weight of approximately 70–75 kDa.
Perforin forms transmembrane channels similar to complement component C9 and shows homology with it. Expression is restricted to killer cell lines, not found in helper T cells or other tumor cells. It is a key effector molecule in T-cell- and NK-cell-mediated cytolysis. Mutations in the perforin gene are associated with familial hemophagocytic lymphohistiocytosis type 2 (HPLH2), a rare autosomal recessive disorder of early childhood. Alternative splicing results in multiple transcript variants.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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