Thermo Fisher Scientific ASL Monoclonal Antibody (OTI9G2), TrueMAB

Applications

Product Specifications

Product Specific Information

For reconstitution, add 100 µL of distilled water to obtain a final antibody concentration of approximately 1 mg/mL.
For conjugation experiments using the carrier-free antibody, perform an additional desalting step (e.g., Zeba Spin Desalting Columns, 7K MWCO, 0.5 mL, Product #89882).

Target Information

ASL encodes a member of the lyase 1 family. The encoded protein forms a cytosolic homotetramer and catalyzes the reversible hydrolytic cleavage of argininosuccinate into arginine and fumarate — an essential step in ammonia detoxification via the urea cycle in the liver.
Mutations in this gene cause argininosuccinic aciduria (argininosuccinic acid lyase deficiency), an autosomal recessive disorder.
A nontranscribed pseudogene is located on the long arm of chromosome 22. Alternatively spliced transcript variants encoding different isoforms have been described.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.