Thermo Fisher Scientific Glypican 3 Polyclonal Antibody

Applications

Tested Dilution

Publications

Western Blot (WB)

1:500-1:2,000

-

ELISA (ELISA)

1 µg/mL

-

Product Specifications

Species Reactivity

Human, Mouse, Rat

Host/Isotype

Rabbit / IgG

Class

Polyclonal

Type

Antibody

Immunogen

Recombinant fusion protein containing a sequence corresponding to amino acids 290-550 of human GPC3 if (typeof window.$mangular === undefined || !window.$mangular) { window.$mangular = {}; } $mangular.antigenJson = \[{targetFamily:Glypican 3,uniProtId:P51654-1,ncbiNodeId:9606,antigenRange:290-550,antigenLength:580,antigenImageFileName:PA5-89561_Glypican_3_P51654-1_Rabbit.svg,antigenImageFileNamePDP:PA5-89561_Glypican_3_P51654-1_Rabbit_PDP.jpeg,sortOrder:1}\]; $mangular.isB2BCMGT = false; $mangular.isEpitopesModalImageMultiSizeEnabled = true;

View immunogen .st0{fill:#FFFFFF;} .st1{fill:#1E8AE7;}

Conjugate

Unconjugated Unconjugated Unconjugated

Form

Liquid

Concentration

0.51 mg/mL

Purification

Affinity Chromatography

Storage buffer

PBS, pH 7.3, with 50% glycerol

Contains

0.02% sodium azide

Storage conditions

-20° C, Avoid Freeze/Thaw Cycles

Shipping conditions

Wet ice

RRID

AB_2805653

Product Specific Information

Immunogen sequence: VEIDKYWREY ILSLEELVNG MYRIYDMENV LLGLFSTIHD SIQYVQKNAG KLTTTIGKLC AHSQQRQYRS AYYPEDLFID KKVLKVAHVE HEETLSSRRR ELIQKLKSFI SFYSALPGYI CSHSPVAEND TLCWNGQELV ERYSQKAARN GMKNQFNLHE LKMKGPEPVV SQIIDKLKHI NQLLRTMSMP KGRVLDKNLD EEGFESGDCG DDEDECIGGS GDGMIKVKNQ LRFLAELAYD LDVDDAPGNS QQATPKDNEI S; Positive Samples: Mouse kidney, Rat testis; Cellular Location: Cell membrane, Extracellular side, GPI-anchor, Lipid-anchor, extracellular space

Target Information

GPC3 is a cell surface proteoglycan that bears heparan sulfate. This protein may be involved in the suppression/modulation of growth in the predominantly mesodermal tissues and organs, and may play a role in the modulation of IGF2 interactions with its receptor and thereby modulate its function. Members of the glypican-related integral membrane proteoglycan family contain a core protein anchored to the cytoplasmic membrane via a glycosyl phosphatidylinositol (GPI) linkage. These proteins may play a role in the control of cell division, growth regulation, and tumor predisposition. Deletion mutations in GPC3 are the cause of Simpson-Golabi-Behmel syndrome (SGBS), also known as Simpson dysmorphia syndrome (SDYS). SGBS is a condition characterized by pre- and postnatal overgrowth (gigantism) with visceral and skeletal anomalies.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.