Thermo Fisher Scientific Cathepsin A (Cleaved Arg326) Polyclonal Antibody

Applications

Western Blot (WB)

• Tested Dilution: 1:500–1:1,000

Product Specifications

Product Specific Information

The antibody was affinity-purified from rabbit antiserum by affinity chromatography using an epitope-specific immunogen. The purity is greater than 95% as determined by SDS-PAGE.

Target Information

Cathepsin A, also known as protective protein/cathepsin A (PPCA), is a lysosomal serine protease encoded by the CTSA gene. It belongs to the alpha/beta hydrolase fold family and shares structural homology with yeast carboxypeptidase Y. Cathepsin A functions mainly in protein degradation within acidic endo/lysosomal compartments and participates in various physiological processes such as intracellular protein degradation, energy metabolism, immune response, and peptide synthesis.
Cleavage at Arg326 is significant for activation or functional modification. Cathepsin A forms a multi-enzyme complex with neuraminidase and beta-galactosidase, essential for lysosomal degradation pathways. Mutations in CTSA are linked to galactosialidosis, a lysosomal storage disorder.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.