Thermo Fisher Scientific Cathepsin A (Cleaved Arg326) Polyclonal Antibody
Human, Mouse, Rat에 반응하는 Rabbit Polyclonal 항체로, Cleaved Cathepsin A (Arg326) 인식. Western blot에 적합하며, 항원 친화 크로마토그래피로 정제됨. 액상 형태로 1 mg/mL 농도, PBS/glycerol buffer에 보관. 연구용으로만 사용.
- 카탈로그번호
- PA576127
- 판매단위
- pk
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Applications
Western Blot (WB)
- Tested Dilution: 1:500–1:1,000
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human, Mouse, Rat |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | Synthetic peptide corresponding to amino acids 291–340 of Human Cleaved-Cathepsin A |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Purification | Antigen affinity chromatography |
| Storage Buffer | PBS, pH 7.2, with 50% glycerol |
| Contains | 0.02% sodium azide |
| Storage Conditions | Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles. |
| Shipping Conditions | Wet ice |
| RRID | AB_2719854 |
Product Specific Information
The antibody was affinity-purified from rabbit antiserum by affinity chromatography using an epitope-specific immunogen. The purity is greater than 95% as determined by SDS-PAGE.
Target Information
Cathepsin A, also known as protective protein/cathepsin A (PPCA), is a lysosomal serine protease encoded by the CTSA gene. It belongs to the alpha/beta hydrolase fold family and shares structural homology with yeast carboxypeptidase Y. Cathepsin A functions mainly in protein degradation within acidic endo/lysosomal compartments and participates in various physiological processes such as intracellular protein degradation, energy metabolism, immune response, and peptide synthesis.
Cleavage at Arg326 is significant for activation or functional modification. Cathepsin A forms a multi-enzyme complex with neuraminidase and beta-galactosidase, essential for lysosomal degradation pathways. Mutations in CTSA are linked to galactosialidosis, a lysosomal storage disorder.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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