Thermo Fisher Scientific Cathepsin A (Cleaved Arg326) Polyclonal Antibody

Applications

Tested Dilution

Publications

Western Blot (WB)

1:500-1:1,000

-

Product Specifications

Species Reactivity

Human, Mouse, Rat

Host/Isotype

Rabbit / IgG

Class

Polyclonal

Type

Antibody

Immunogen

Synthetic peptide corresponding to amino acids 291-340 of Human Cleaved-Cathepsin A.

Conjugate

Unconjugated Unconjugated Unconjugated

Form

Liquid

Concentration

1 mg/mL

Purification

Antigen affinity chromatography

Storage buffer

PBS, pH 7.2, with 50% glycerol

Contains

0.02% sodium azide

Storage conditions

Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.

Shipping conditions

Wet ice

RRID

AB_2719854

Product Specific Information

The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is > 95% (by SDS-PAGE).

Target Information

Cathepsin A, also known as protective protein/cathepsin A (PPCA), is a lysosomal serine protease encoded by the CTSA gene. It is a member of the alpha/beta hydrolase fold family, sharing structural homology with yeast carboxypeptidase Y. Cathepsin A functions predominantly in protein degradation within acidic endo/lysosomal compartments. It is involved in numerous physiological processes including intracellular protein degradation, energy metabolism, immune responses, and peptide synthesis. Particularly, the cleavage at Arg326 is significant as it pertains to its activation or functional modifications. Cathepsin A operates in conjunction with other enzymes such as neuraminidase and beta-galactosidase in a multi-enzyme complex, which is crucial for the lysosomal degradation pathways. Dysfunctions or mutations in the CTSA gene are associated with galactosialidosis, a lysosomal storage disorder characterized by a deficiency in these enzymatic activities.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.