Thermo Fisher Scientific c-Myc Polyclonal Antibody

Thermo Fisher Scientific c-Myc Polyclonal Antibody

Applications and Tested Dilution

Product Specifications

Product Specific Information

• Keep as concentrated solution.
• Predicted reactivity: Mouse (89%), Rat (86%), Dog (93%), Cat (91%), Pig (94%), Rabbit (93%), Sheep (92%), Rhesus Monkey (98%), Chimpanzee (99%), Bovine (92%).
• Positive Control: 293T, NIH-3T3, Raw264.7, HeLa, HeLa nuclear extract.
• Store product as a concentrated solution. Centrifuge briefly prior to opening the vial.

Target Information

The c-Myc protein is a 62 kDa transcription factor encoded by the c-Myc gene on human chromosome 8q24. It is commonly activated in various tumor cells and plays crucial roles in cellular proliferation, differentiation, apoptosis, and cell cycle progression.

Phosphorylation at Thr58/Ser62 by glycogen synthase kinase 3, cyclin-dependent kinase, ERK2, and JNK has been shown to influence cell cycle regulation. c-Myc is essential for vasculogenesis and angiogenesis in tumor development.

The c-myc oncogene (p62 c-myc) regulates normal cellular proliferation and differentiation, while deregulated expression induces apoptosis in different cell types. Antibodies against c-myc epitopes recognize overexpressed proteins containing Myc epitope tags fused to amino- or carboxy-termini of target proteins.

Amplification of the c-Myc gene is observed in several human tumors including lung, breast, and colon carcinomas. Translocation of the c-myc locus on chromosome 8 to immunoglobulin loci (chromosome 14, 2, or 22) is associated with Burkitt’s lymphoma and other B-cell lymphoproliferative diseases. Aberrant expression of c-myc occurs in tumors of various origins such as colorectal, gastric, hepatic, mammary, ovarian, pulmonary, and hematopoietic neoplasms.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.