Thermo Fisher Scientific INSR alpha Recombinant Mouse Monoclonal Antibody (83-14)
INSR alpha 단백질을 인식하는 mouse recombinant monoclonal antibody (Clone 83-14). Western blot, IHC, ICC, ELISA, IP 등 다양한 응용 가능. HEK293 발현, Protein A 정제, 1 mg/mL 농도. 인간, 소, 양, 돼지 반응성.
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Thermo Fisher Scientific INSR alpha Recombinant Mouse Monoclonal Antibody (83-14)
Applications and Tested Dilution
- Western Blot (WB): Assay-dependent
- Immunohistochemistry (IHC): Assay-dependent
- Immunocytochemistry (ICC/IF): Assay-dependent
- ELISA: Assay-dependent
- Immunoprecipitation (IP): Assay-dependent
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Bovine, Human, Sheep, Pig |
| Host / Isotype | Mouse / IgG2a, kappa |
| Expression System | HEK293 cells |
| Class | Recombinant Monoclonal |
| Type | Antibody |
| Clone | 83-14 |
| Immunogen | Mice immunized with IM-9 lymphocytes followed by purified insulin receptor |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Purification | Protein A |
| Storage Buffer | PBS |
| Contains | 0.02% ProClin 300 |
| Storage Conditions | Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles. |
| Shipping Conditions | Wet ice |
Product Specific Information
Recognises the extracellular domain of the Insulin Receptor alpha.
Amino acids 469–592 (exon 7 and 8) of Insulin Receptor alpha.
Target Information
The biological actions of insulin and IGF-1 are mediated by their respective cell surface receptor tyrosine kinases that regulate multiple signaling pathways through activation of phosphorylation cascades.
Insulin/IGF-1 binding to the extracellular domain leads to autophosphorylation of downstream target proteins.
Differences in sequence and intracellular signaling domains result in distinct functional consequences for each receptor.
Defects in IR are associated with insulin resistance syndromes; IGF-1R defects may cause growth retardation.
Both signaling cascades are also involved in cancer development.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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