Thermo Fisher Scientific EpCAM Recombinant Mouse Monoclonal Antibody (KS1/4)
EpCAM 단백질을 인식하는 마우스 단일클론 항체로, 인간 시료에 반응합니다. ICC/IF, 유세포분석, ELISA 등 다양한 실험에 사용 가능합니다. Recombinant 형식으로 HEK293 세포에서 발현되었으며, Protein A로 정제되었습니다. EpCAM 발현 암세포 연구에 적합합니다.
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Applications and Tested Dilutions
| Application | Tested Dilution |
|---|---|
| Immunocytochemistry (ICC/IF) | Assay-dependent |
| Flow Cytometry (Flow) | Assay-dependent |
| ELISA | Assay-dependent |
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human |
| Host / Isotype | Mouse / IgG2a, kappa |
| Expression System | HEK293 cells |
| Class | Recombinant Monoclonal |
| Type | Antibody |
| Clone | KS1/4 |
| Immunogen | The original antibody was generated by immunizing BALB/c mice with human adenocarcinoma of the lung cell line UCLA P3. Target: EpCAM (CD326), UniProt ID: P16422-1, Antigen Range: 1–314 |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Purification | Protein A |
| Storage Buffer | PBS |
| Contains | 0.02% ProClin 300 |
| Storage Conditions | Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles. |
| Shipping Conditions | Wet ice |
Product Specific Information
This antibody binds to the EpCAM receptor, which is expressed on the surface of adenocarcinomas and on almost all epithelial cell membranes except mesodermal and neural cell membranes.
Target Information
Ep-CAM (epithelial adhesion molecule, epithelial specific antigen, ESA) is a transmembrane glycoprotein (~40 kDa) expressed in epithelial tissues. It functions as a calcium-independent cell adhesion molecule, influencing cell cycle, proliferation, and metabolism by inducing the proto-oncogene c-myc and cell cycle regulators cyclin A and cyclin E.
Ep-CAM-mediated adhesions negatively regulate cadherin-mediated adhesions, affecting epithelial differentiation and growth. Overexpression of Ep-CAM is associated with enhanced epithelial proliferation and is a marker for tumors of epithelial origin.
Ep-CAM is expressed on the baso-lateral surface of most simple epithelia and many carcinoma types, and can distinguish adenocarcinomas from pleural mesotheliomas.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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