Thermo Fisher Scientific CFTR (Cystic Fibrosis Transmembrane Conductance Regulator) Recombinant Rabbit Monoclonal Antibody (CFTR/7154R)

Applications

Immunohistochemistry (Paraffin) (IHC (P))

• Tested Dilution: 1–2 µg/mL

Product Specifications

Product Specific Information

• Antibody is stable for 24 months.
• Positive Control: Human pancreas, kidney, or placenta
• Cellular Localization: Cell surface, Cytoplasm

Specificity Comments

Recognizes a protein of 165–170 kDa, identified as cystic fibrosis transmembrane conductance regulator (CFTR).
CFTR consists of two membrane-spanning domains (MSD), two nucleotide-binding domains (NBD), and an R domain.
It is structurally similar to multidrug resistance (Mdr1) protein, both belonging to the ATP-binding cassette (ABC) transporter superfamily.
CFTR functions as a small conductance cAMP-activated chloride ion channel located in the apical membranes of epithelia in the pancreas, airway, intestine, bile duct, sweat gland, and male genital ducts.
CFTR serves as a valuable marker of human pancreatic duct cell development and differentiation.

Target Information

Cystic Fibrosis (CF) is a common lethal genetic disease caused by mutations in the gene encoding the cystic fibrosis transmembrane conductance regulator (CFTR), a cAMP-regulated chloride channel.
Approximately 70% of CF cases involve deletion of phenylalanine at position 508 (ΔF508), leading to defective chloride transport.
CF is often fatal due to lung and liver disease. Interestingly, CFTR also plays a role in host-pathogen interactions: Salmonella typhi uses CFTR to enter intestinal epithelial cells, and ΔF508 mice show significantly reduced bacterial uptake.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.