Thermo Fisher Scientific Phospho-SCNN1B (Ser633) Polyclonal Antibody

Thermo Fisher Scientific Phospho-SCNN1B (Ser633) Polyclonal Antibody

Applications and Tested Dilution

Publications

• Miscellaneous PubMed (Misc): –
• View 3 publications

Product Specifications

Product Specific Information

• Reconstitute in 100 µL of sterile water.
• Centrifuge to remove any insoluble material.
• The antigen is homologous with the corresponding sequence in mouse.
• Specificity: SCNN1B.

Target Information

Sodium permeable non-voltage-sensitive ion channel inhibited by the diuretic amiloride. Mediates electrodiffusion of luminal sodium (and water) through epithelial cell apical membranes. Controls sodium reabsorption in kidney, colon, lung, and sweat glands, and plays a role in taste perception.
Forms a heterotetramer of two alpha, one beta, and one gamma subunit; a delta subunit can replace the alpha subunit.
Interacts with WW domains of NEDD4, NEDD4L, WWP1, and WWP2.

Defects in SCNN1B cause:

• Autosomal recessive pseudohypoaldosteronism type 1 (PHA1) – a rare salt-wasting disease due to mineralocorticoid unresponsiveness.
• Liddle syndrome – an autosomal dominant pseudoaldosteronism with hypertension and hypokalemic alkalosis.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.

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