Thermo Fisher Scientific Phospho-SCNN1B (Ser633) Polyclonal Antibody
SCNN1B 단백질의 Ser633 인산화 부위를 인식하는 다클론 항체로, IHC에 최적화되어 있습니다. 쥐 및 랫트 반응성이 있으며, 동결건조 형태로 제공됩니다. 연구용으로만 사용되며 장기 보관 시 -20°C에서 안정적입니다.
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Thermo Fisher Scientific Phospho-SCNN1B (Ser633) Polyclonal Antibody
Applications and Tested Dilution
| Application | Tested Dilution |
|---|---|
| Immunohistochemistry (IHC) | 1:300–1:2,000 |
Publications
- Miscellaneous PubMed (Misc): –
- View 3 publications
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Mouse, Rat |
| Published Species | Not Applicable |
| Host / Isotype | Sheep / Ig |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | A synthetic peptide to phospho S633 of rat amiloride-sensitive sodium channel subunit beta (SCNN1B, SCNEB) conjugated to an immunogenic carrier protein |
| Conjugate | Unconjugated |
| Form | Lyophilized |
| Concentration | Not Determined |
| Storage Buffer | Whole serum |
| Contains | No preservative |
| Storage Conditions | Store at 4°C short term. For long-term storage, store at -20°C, avoiding freeze/thaw cycles. Glycerol (1:1) may be added for added stability. |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
Product Specific Information
- Reconstitute in 100 µL of sterile water.
- Centrifuge to remove any insoluble material.
- The antigen is homologous with the corresponding sequence in mouse.
- Specificity: SCNN1B.
Target Information
Sodium permeable non-voltage-sensitive ion channel inhibited by the diuretic amiloride. Mediates electrodiffusion of luminal sodium (and water) through epithelial cell apical membranes. Controls sodium reabsorption in kidney, colon, lung, and sweat glands, and plays a role in taste perception.
Forms a heterotetramer of two alpha, one beta, and one gamma subunit; a delta subunit can replace the alpha subunit.
Interacts with WW domains of NEDD4, NEDD4L, WWP1, and WWP2.
Defects in SCNN1B cause:
- Autosomal recessive pseudohypoaldosteronism type 1 (PHA1) – a rare salt-wasting disease due to mineralocorticoid unresponsiveness.
- Liddle syndrome – an autosomal dominant pseudoaldosteronism with hypertension and hypokalemic alkalosis.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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