Thermo Fisher Scientific Synaptotagmin 1 Polyclonal Antibody
Rabbit polyclonal antibody against Synaptotagmin 1 for WB and IHC applications. Recognizes mouse and rat species. Lyophilized form with PBS buffer, no preservative. Suitable for neuroscience research on synaptic vesicle function and Ca2+-dependent exoc...
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- OSS00141G-500UG
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Applications
| Application | Tested Dilution | Publications |
|---|---|---|
| Western Blot (WB) | 10–50 µg/mL | - |
| Immunohistochemistry (IHC) | 10–50 µg/mL | - |
| Miscellaneous (PubMed) | - | View 2 publications |
Product Specifications
| Property | Description |
|---|---|
| Species Reactivity | Mouse, Rat |
| Published Species | Not Applicable |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | Synthetic peptide from aa region 10–60 of rat Synaptotagmin 1 conjugated to blue carrier protein |
| Conjugate | Unconjugated |
| Form | Lyophilized |
| Concentration | Not determined |
| Purification | Ammonium sulfate precipitation |
| Storage Buffer | PBS |
| Contains | No preservative |
| Storage Conditions | Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles. Glycerol (1:1) may be added for stability. |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
Product Specific Information
- Reconstitute in 500 µL of sterile water. Centrifuge to remove any insoluble material.
- The antigen is homologous in mouse.
- Specificity: SYTI.
Target Information
Synaptotagmin 1 is a synaptic vesicle membrane glycoprotein widely expressed throughout the CNS. It acts as a Ca²⁺ sensor in the regulation of exocytosis and neurotransmitter release.
Studies indicate that Ca²⁺-mediated binding of Synaptotagmin 1 to SNAP25 is essential for triggering membrane fusion. Specific residues within the C2B domain influence endocytic rate and vesicle size.
Synaptotagmin 1 binds acidic phospholipids requiring both an acidic head group and diacyl backbone. It interacts with receptors for activated protein kinase C in a Ca²⁺-dependent manner and binds neurexins, syntaxin, and AP2 in a Ca²⁺-independent manner.
Dysfunction of Synaptotagmin 1 is associated with food-borne and infant botulism.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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