Thermo Fisher Scientific RUNX2 Monoclonal Antibody (1D8)

Applications and Tested Dilutions

Product Specifications

Product Specific Information

Sequence of this protein is as follows:
NPRPSLNSAP SPFNPQGQSQ ITDPRQAQSS PPWSYDQSYP SYLSQMTSPS IHSTTPLSST RGTGLPAITD VPRRISDDDT ATSDFCLWPS TLSKKSQAGA

Target Information

RUNX2 is a nuclear transcription factor belonging to the RUNX family, containing a Runt DNA-binding domain. It is essential for both membranous and endochondral bone formation. RUNX2 regulates osteoblastic differentiation and skeletal morphogenesis, and serves as a scaffold for nucleic acids and regulatory factors in skeletal gene expression. It can bind DNA as a monomer or more effectively as a subunit of a heterodimeric complex. RUNX2 also increases TGFBR1 expression in osteoblasts and cooperates with DLX5 or related factors to activate osteoblast-specific gene expression. Mutations in RUNX2 cause bone development disorders such as cleidocranial dysplasia (CCD).

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.