Thermo Fisher Scientific RUNX2 Monoclonal Antibody (1D8)
RUNX2 단백질을 인식하는 Mouse monoclonal antibody로, WB, IHC, ICC, ELISA 등 다양한 응용에 사용 가능. 인간 시료 반응성. Affinity chromatography로 정제된 액상형 항체로, PBS buffer에 보존되며 방부제 무첨가. 연구용으로만 사용.
- 카탈로그번호
- H00000860-M01
- 판매단위
- pk
카탈로그
1개 옵션 · 카탈로그 번호를 클릭하면 복사됩니다Thermo Fisher Scientific · Thermo Fisher Scientific RUNX2 Monoclonal Antibody (1D8)
Applications and Tested Dilutions
| Application | Tested Dilution |
|---|---|
| Western Blot (WB) | 1–5 µg/mL |
| Immunohistochemistry (Paraffin) (IHC (P)) | 3 µg/mL |
| Immunocytochemistry (ICC/IF) | 10 µg/mL |
| ELISA | 0.03 ng/mL |
Product Specifications
| Specification | Description |
|---|---|
| Species Reactivity | Human |
| Host / Isotype | Mouse / IgG2b |
| Class | Monoclonal |
| Type | Antibody |
| Clone | 1D8 |
| Immunogen | RUNX2 (NP_004339, 251–350 a.a.) partial recombinant protein with GST tag (GST tag MW: 26 kDa) |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | See Label |
| Purification | Affinity chromatography |
| Storage Buffer | PBS, pH 7.4 |
| Contains | No preservative |
| Storage Conditions | -20°C, Avoid Freeze/Thaw Cycles |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
Product Specific Information
Sequence of this protein is as follows:
NPRPSLNSAP SPFNPQGQSQ ITDPRQAQSS PPWSYDQSYP SYLSQMTSPS IHSTTPLSST RGTGLPAITD VPRRISDDDT ATSDFCLWPS TLSKKSQAGA
Target Information
RUNX2 is a nuclear transcription factor belonging to the RUNX family, containing a Runt DNA-binding domain. It is essential for both membranous and endochondral bone formation. RUNX2 regulates osteoblastic differentiation and skeletal morphogenesis, and serves as a scaffold for nucleic acids and regulatory factors in skeletal gene expression. It can bind DNA as a monomer or more effectively as a subunit of a heterodimeric complex. RUNX2 also increases TGFBR1 expression in osteoblasts and cooperates with DLX5 or related factors to activate osteoblast-specific gene expression. Mutations in RUNX2 cause bone development disorders such as cleidocranial dysplasia (CCD).
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
Thermo Fisher Scientific 상품 둘러보기
전체보기
문의
0개 · 배송·재고 문의는 실시간 상담이 빠릅니다아직 등록된 문의가 없어요.