Thermo Fisher Scientific CASQ2 Polyclonal Antibody, MaxPab

Thermo Fisher Scientific CASQ2 Polyclonal Antibody, MaxPab

Applications

• Western Blot (WB)
  Tested Dilution: 1–5 µg/mL

Product Specifications

Product Specific Information

Sequence of CASQ2 protein:
MKRTHLFIVG IYFLSSCRAE EGLNFPTYDG KDRVVSLSEK NFKQVLKKYD LLCLYYHEPV SSDKVTQKQF QLKEIVLELV AQVLEHKAIG FVMVDAKKEA KLAKKLGFDE EGSLYILKGD RTIEFDGEFA ADVLVEFLLD LIEDPVEIIS SKLEVQAFER IEDYIKLIGF FKSEDSEYYK AFEEAAEHFQ PYIKFFATFD KGVAKKLSLK MNEVDFYEPF MDEPIAIPNK PYTEEELVEF VKEHQRPTLR RLRPEEMFET WEDDLNGIHI VAFAEKSDPD GYEFLEILKQ VARDNTDNPD LSILWIDPDD FPLLVAYWEK TFKIDLFRPQ IGVVNVTDAD SVWMEIPDDD DLPTAEELED WIEDVLSGKI NTEDDDEDDD DDDNSDEEDN DDSDDDDDE

Target Information

Calsequestrin (CASQ) is a Ca²⁺-binding protein found primarily in the junctional sarcoplasmic reticulum of skeletal and cardiac muscle. The cardiac form, CASQ2, is encoded by a separate gene.
CASQ2 primarily buffers sarcoplasmic reticulum Ca²⁺ ions and also regulates the open probability of ryanodine receptor 2 (RyR2).
Mutations in CASQ2 cause stress-induced polymorphic ventricular tachycardia (CPVT2), which may lead to cardiac arrest.

Usage

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.

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