Thermo Fisher Scientific CASQ2 Polyclonal Antibody, MaxPab
CASQ2 단백질을 인식하는 Thermo Fisher Scientific의 토끼 폴리클로날 항체로, Western blot에 최적화되어 있습니다. 인간 시료 반응성이 있으며, 액상 형태로 제공되며 PBS 버퍼에 보존제가 없습니다. 연구용으로만 사용됩니다.
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Thermo Fisher Scientific CASQ2 Polyclonal Antibody, MaxPab
Applications
- Western Blot (WB)
Tested Dilution: 1–5 µg/mL
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | CASQ2 (NP_001223.2, 1–399 a.a.) full-length human protein |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | See Label |
| Purification | Affinity chromatography |
| Storage Buffer | PBS, pH 7.4 |
| Contains | No preservative |
| Storage Conditions | -20°C, Avoid Freeze/Thaw Cycles |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
Product Specific Information
Sequence of CASQ2 protein:
MKRTHLFIVG IYFLSSCRAE EGLNFPTYDG KDRVVSLSEK NFKQVLKKYD LLCLYYHEPV SSDKVTQKQF QLKEIVLELV AQVLEHKAIG FVMVDAKKEA KLAKKLGFDE EGSLYILKGD RTIEFDGEFA ADVLVEFLLD LIEDPVEIIS SKLEVQAFER IEDYIKLIGF FKSEDSEYYK AFEEAAEHFQ PYIKFFATFD KGVAKKLSLK MNEVDFYEPF MDEPIAIPNK PYTEEELVEF VKEHQRPTLR RLRPEEMFET WEDDLNGIHI VAFAEKSDPD GYEFLEILKQ VARDNTDNPD LSILWIDPDD FPLLVAYWEK TFKIDLFRPQ IGVVNVTDAD SVWMEIPDDD DLPTAEELED WIEDVLSGKI NTEDDDEDDD DDDNSDEEDN DDSDDDDDE
Target Information
Calsequestrin (CASQ) is a Ca²⁺-binding protein found primarily in the junctional sarcoplasmic reticulum of skeletal and cardiac muscle. The cardiac form, CASQ2, is encoded by a separate gene.
CASQ2 primarily buffers sarcoplasmic reticulum Ca²⁺ ions and also regulates the open probability of ryanodine receptor 2 (RyR2).
Mutations in CASQ2 cause stress-induced polymorphic ventricular tachycardia (CPVT2), which may lead to cardiac arrest.
Usage
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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