Thermo Fisher Scientific CASQ2 Monoclonal Antibody (1C6)
CASQ2 단백질을 표적하는 Mouse monoclonal 항체로, Western blot, IHC(P), ELISA에 적합합니다. 인간 시료에 반응하며, Affinity chromatography로 정제된 액상 형태입니다. 연구용으로 사용되며, -20°C에서 보관이 권장됩니다.
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Applications and Tested Dilution
| Application | Tested Dilution |
|---|---|
| Western Blot (WB) | 1–5 µg/mL |
| Immunohistochemistry (Paraffin) (IHC (P)) | 3 µg/mL |
| ELISA | 10 µg/mL |
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human |
| Host / Isotype | Mouse / IgG2b, kappa |
| Class | Monoclonal |
| Type | Antibody |
| Clone | 1C6 |
| Immunogen | CASQ2 (AAH22288, 20 a.a. approximately 399 a.a) full-length recombinant protein with GST tag (GST tag MW: 26 kDa) |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | See Label |
| Purification | Affinity chromatography |
| Storage Buffer | PBS, pH 7.4 |
| Contains | No preservative |
| Storage Conditions | -20°C, Avoid Freeze/Thaw Cycles |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
Product Specific Information
Protein Sequence:
EEGLNFPTYD GKDRVVSLSE KNFKQVLKKY DLLCLYYHEP VSSDKVTQKQ FQLKEIVLEL VAQVLEHKAI GFVMVDAKKE AKLAKKLGFD EEGSLYILKG DRTIEFDGEF AADVLVEFLL DLIEDPVEII SSKLEVQAFE RIEDYIKLIG FFKSEDSEYY KAFEEAAEHF QPYIKFFATF DKGVAKKLSL KMNEVDFYEP FMDEPIAIPN KPYTEEELVE FVKEHQRPTL RRLRPEEMFE TWEDDLNGIH IVAFAEKSDP DGYEFLEILK QVARDNTDNP DLSILWIDPD DFPLLVAYWE KTFKIDLFRP QIGVVNVTDA DSVWMEIPDD DDLPTAEELE DWIEDVLSGK INTEDDDEDD DDDDNSDEED NDDSDDDDDETarget Information
Calsequestrin (CASQ) is a Ca²⁺-binding protein primarily located in the junctional sarcoplasmic reticulum of skeletal and cardiac muscle. The cardiac form, CASQ2, is encoded by a separate gene. CASQ2 functions mainly in buffering sarcoplasmic reticulum Ca²⁺ ions and also regulates the open probability of ryanodine receptor 2 (RyR2). Mutations in CASQ2 are associated with stress-induced polymorphic ventricular tachycardia (CPVT2), which can lead to cardiac arrest.
For Research Use Only.
Not for use in diagnostic procedures.
Not for resale without express authorization.
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