Thermo Fisher Scientific Factor XIII B Polyclonal Antibody
Human 및 비인간 영장류 반응성을 가진 Rabbit Polyclonal 항체로, Factor XIII B 단백질 검출에 사용됩니다. Western blot, IHC, ICC 등 다양한 응용에 적합하며, 고순도 Affinity chromatography로 정제된 액상 항체입니다.
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- PA5103753
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- pk
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Thermo Fisher Scientific Factor XIII B Polyclonal Antibody
Applications and Tested Dilution
| Application | Tested Dilution |
|---|---|
| Western Blot (WB) | 1:1,000–1:3,000 |
| Immunohistochemistry (Paraffin) (IHC (P)) | 1:50–1:200 |
| Immunocytochemistry (ICC/IF) | 1:100–1:500 |
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human, Non-human primate |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | A synthesized peptide derived from human F13B (Accession P05160), corresponding to amino acid residues G249–H299 |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Purification | Affinity chromatography |
| Storage Buffer | PBS, pH 7.4, with 50% glycerol |
| Contains | 0.02% sodium azide |
| Storage Conditions | -20°C |
| Shipping Conditions | Wet ice |
| RRID | AB_2853086 |
Product Specific Information
Antibody detects endogenous levels of total F13B.
Target Information
This gene encodes coagulation factor XIII B subunit. Coagulation factor XIII is the last zymogen to become activated in the blood coagulation cascade. Plasma factor XIII is a heterotetramer composed of 2 A subunits and 2 B subunits. The A subunits have catalytic function, and the B subunits do not have enzymatic activity but may serve as plasma carrier molecules. Platelet factor XIII is comprised only of 2 A subunits, identical to those of plasma origin. Upon activation by thrombin cleavage and in the presence of calcium ions, plasma factor XIII dissociates its B subunits and yields the active enzyme factor XIIIa, which acts as a transglutaminase to catalyze crosslinking between fibrin molecules, stabilizing the fibrin clot. Factor XIII deficiency is classified into two categories: type I (lack of both A and B subunits) and type II (lack of A subunit only), leading to bleeding tendency, defective wound healing, and habitual abortion.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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