Thermo Fisher Scientific MCU Polyclonal Antibody
MCU 단백질을 인식하는 Rabbit Polyclonal Antibody로, Western blot 및 IHC(P) 실험에 사용 가능. 인간과 마우스 시료에 반응하며, 액상 형태로 1 mg/mL 농도 유지. 미토콘드리아 칼슘 수송 연구에 적합.
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Applications and Tested Dilution
| Application | Tested Dilution |
|---|---|
| Western Blot (WB) | 1:1,000–1:3,000 |
| Immunohistochemistry (Paraffin) (IHC (P)) | 1:50–1:200 |
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human, Mouse |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | A synthesized peptide derived from human MCU (Accession Q8NE86), corresponding to amino acid residues S92–D142 |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Purification | Affinity chromatography |
| Storage Buffer | PBS, pH 7.4, with 50% glycerol |
| Contains | 0.02% sodium azide |
| Storage Conditions | -20°C |
| Shipping Conditions | Wet ice |
| RRID | AB_2853087 |
Product Specific Information
Antibody detects endogenous levels of total CCDC109A.
Target Information
Mitochondrial inner membrane calcium uniporter (MCU) mediates calcium uptake into mitochondria and forms the calcium-conducting subunit of the uniporter complex (uniplex). Its activity is regulated by MICU1 and MICU2—down-regulated at low Ca²⁺ levels and enhanced at higher Ca²⁺ levels. MCU plays a critical role in mitochondrial calcium homeostasis, influencing cellular bioenergetics, calcium signaling, and apoptosis pathways. It also contributes to calcium buffering in cardiomyocytes, regulates mitochondrial calcium loading during acute stress, and affects insulin secretion, muscle size, and synaptic vesicle endocytosis.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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