Thermo Fisher Scientific SCN9A Polyclonal Antibody

Applications

Western Blot (WB)

• Tested Dilution: 1:1,000

Product Specifications

Product Specific Information

Antibody detects endogenous levels of total Nav1.7.

Target Information

Epithelial sodium channels (ENaC) are amiloride-sensitive ion channels belonging to the Degenerin/epithelial sodium channel (Deg/ENaC) superfamily. These channels share structural similarity with two short intracellular termini, two transmembrane segments, and a large extracellular loop containing a conserved cysteine-rich region. ENaC has three homologous isoforms (α, β, γ) and plays a critical role in sodium and fluid balance across epithelial tissues such as kidney, lung, and colon. It mediates aldosterone-dependent sodium reabsorption in the distal nephron, regulating blood pressure. ENaC activity is modulated partly through interaction with the CFTR chloride channel. Gain-of-function mutations in β- or γ-ENaC can cause Liddle’s syndrome (hypertension), while loss-of-function mutations in α- or β-ENaC lead to pseudohypoaldosteronism type 1 (PHA-1).

For Research Use Only.
Not for use in diagnostic procedures.
Not for resale without express authorization.