Thermo Fisher Scientific Myosin-9 Polyclonal Antibody
Rabbit polyclonal antibody targeting human Myosin-9 (MYH9), validated for WB and IP. Recognizes region 1900–1950 of MYH9 heavy chain. Supplied unconjugated in liquid form, 1 mg/mL concentration. Ideal for research on cytoskeletal dynamics and MYH9-rela...
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- A304490A
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Applications
Western Blot (WB)
- Tested Dilution: 1:2,000–1:10,000
Immunoprecipitation (IP)
- Tested Dilution: 2–10 µg/mg lysate
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human, Mouse |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | Region between residue 1900 to 1950 of human Myosin Heavy Chain 9 |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Purification | Antigen affinity chromatography |
| Storage Buffer | Phosphate/tris citrate, pH 7–8 |
| Contains | 0.09% sodium azide |
| Storage Conditions | 4°C |
| Shipping Conditions | Wet ice |
Product Specific Information
The recommended shelf life for this product is 1 year from date of receipt.
Target Information
The MYH9 gene, located on chromosome 22q12.3, encodes the heavy chain of non-muscle myosin IIA (NMHC IIA), a critical component of the actin cytoskeleton. It plays essential roles in cellular processes such as migration, adhesion, division, and maintenance of cell shape.
Structurally, MYH9 spans over 106 kilobases with 41 exons, encoding a protein of 1,960 amino acids forming a hexameric complex (two heavy chains, two regulatory light chains, two essential light chains). Mutations in MYH9 lead to MYH9-related diseases (MYH9-RD), including May-Hegglin anomaly, Fechtner syndrome, and Epstein syndrome, characterized by macrothrombocytopenia and potential hearing loss, renal failure, or cataracts.
MYH9 is crucial for hematopoiesis, supporting hematopoietic stem and progenitor cell survival. Loss of MYH9 function can cause severe blood cell deficiencies and bone marrow failure.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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