Thermo Fisher Scientific Myosin-9 Polyclonal Antibody
Myosin-9 단백질을 인식하는 Thermo Fisher Scientific의 토끼 폴리클로날 항체로, Western blot 및 면역침전(IP)에 적합합니다. 사람 MYH9 단백질(1900–1950 aa) 영역을 면역원으로 사용하며, 1 mg/mL 액상 형태로 제공됩니다. 연구용으로만 사용 가능합니다.
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Applications and Tested Dilution
| Application | Tested Dilution |
|---|---|
| Western Blot (WB) | 1:2,000–1:10,000 |
| Immunoprecipitation (IP) | 2–10 µg/mg lysate |
Product Specifications
| 항목 | 내용 |
|---|---|
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | Region between residue 1900 to 1950 of human Myosin Heavy Chain 9 |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Storage Conditions | 4°C |
| Shipping Conditions | Wet ice |
Product Specific Information
The recommended shelf life for this product is 1 year from date of receipt.
Target Information
The MYH9 gene, located on chromosome 22q12.3, encodes the heavy chain of non-muscle myosin IIA (NMHC IIA), a key component of the actin cytoskeleton that regulates essential cellular processes such as migration, adhesion, division, and shape maintenance.
The MYH9 gene spans over 106 kilobases with 41 exons encoding a 1,960-amino-acid protein forming a hexameric complex (two heavy chains, two regulatory light chains, and two essential light chains).
Mutations in MYH9 cause autosomal dominant MYH9-related diseases (MYH9-RD) such as May-Hegglin anomaly, Fechtner syndrome, and Epstein syndrome. These disorders are characterized by macrothrombocytopenia and can lead to hearing loss, renal failure, and cataracts.
MYH9 also plays a crucial role in hematopoiesis, being necessary for the survival and maintenance of hematopoietic stem and progenitor cells (HSPCs). Loss of MYH9 function disrupts blood cell formation, leading to severe deficiencies and bone marrow failure.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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