Thermo Fisher Scientific Huntingtin Recombinant Rabbit Monoclonal Antibody (3H2L4)

Applications

Immunocytochemistry (ICC/IF)

• Tested Dilution: 5 µg/mL

Product Specifications

Product Specific Information

This antibody is predicted to react with Monkey, Mouse, and Bovine.

Recombinant rabbit monoclonal antibodies are produced using in vitro expression systems. These systems clone specific antibody DNA sequences from immunoreactive rabbits. Individual clones are screened to select the best candidates for production.

Advantages:

• High specificity and sensitivity
• Lot-to-lot consistency
• Animal origin-free formulation
• Broader immunoreactivity due to larger rabbit immune repertoire

Target Information

Huntingtin is a disease gene linked to Huntington’s disease (HD), a neurodegenerative disorder characterized by loss of striatal neurons. This is caused by an expanded, unstable trinucleotide repeat in the huntingtin gene, translating as a polyglutamine repeat in the protein product.

HD typically manifests in mid-life as an autosomal dominant neurodegenerative disease characterized by psychiatric disorders, dementia, and involuntary movements (chorea), leading to death within 10–20 years.

The huntingtin locus spans approximately 180 kb and consists of 67 exons. It is widely expressed and required for normal development. Two alternatively polyadenylated forms exist, showing different abundance in fetal and adult tissues. The larger transcript (~13.7 kb) is predominant in brain, while the smaller (~10.3 kb) is more broadly expressed.

The genetic defect leading to Huntington’s disease may not eliminate transcription but may alter mRNA properties or protein function.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.