Thermo Fisher Scientific Cardiac Troponin T Recombinant Rabbit Monoclonal Antibody (17H8L13)

Applications

Immunocytochemistry (ICC/IF)

• Tested Dilution: Assay-dependent

Flow Cytometry (Flow)

• Tested Dilution: Not specified
• Publications: View 3 publications

Product Specifications

Product Specific Information

Recombinant rabbit monoclonal antibodies are produced using in vitro expression systems. These systems clone specific antibody DNA sequences from immunoreactive rabbits, followed by screening to select optimal clones for production.
Advantages include:

• Improved specificity and sensitivity
• Lot-to-lot consistency
• Animal origin-free formulations
• Broader immunoreactivity due to the rabbit immune repertoire

Target Information

Cardiac Troponin T is the tropomyosin-binding subunit of the troponin complex located on the thin filament of striated muscles. It regulates muscle contraction in response to changes in intracellular calcium ion concentration and is essential for muscle function and myofibril formation.
In the human heart, four cTnT isoforms are expressed developmentally. Expression levels are affected by heart failure. Mutations in Cardiac Troponin T are associated with familial hypertrophic and dilated cardiomyopathy. The gene undergoes alternative splicing, producing multiple tissue-specific isoforms.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.