Thermo Fisher Scientific DNMT3A Polyclonal Antibody
DNMT3A 단백질을 인식하는 Thermo Fisher Scientific의 토끼 폴리클로날 항체. Western blot 및 IHC(P) 검증 완료. 인간, 마우스, 랫트 반응성. Protein G 정제, PBS 버퍼에 0.09% sodium azide 포함. 4°C 단기, -20°C 장기 보관 권장.
- 카탈로그번호
- PA511158
- 판매단위
- pk
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Applications and Tested Dilution
| Application | Tested Dilution |
|---|---|
| Western Blot (WB) | 1:1,000 |
| Immunohistochemistry (Paraffin) (IHC (P)) | 1:50–1:100 |
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human, Mouse, Rat |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | KLH-conjugated synthetic peptide corresponding to amino acids 457–486 of human DNMT3A |
| Conjugate | Unconjugated |
| Form | Liquid |
| Purification | Protein G |
| Storage Buffer | PBS, pH 7.4 |
| Contains | 0.09% sodium azide |
| Storage Conditions | Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles. |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
| RRID | AB_10982312 |
Product Specific Information
This antibody is predicted to react with chicken, mouse, and rat based on sequence homology.
Target Information
Methylation of DNA at cytosine residues plays an important role in gene expression regulation, genomic imprinting, and mammalian development. Aberrant methylation patterns, such as hypermethylation of tumor suppressor genes or hypomethylation of genomic DNA, are associated with cancer development. Three families of mammalian DNA methyltransferases have been identified: Dnmt1, Dnmt2, and Dnmt3.
- Dnmt1 is constitutively expressed in proliferating cells; its inactivation leads to global genomic demethylation and embryonic lethality.
- Dnmt2 is expressed at low levels in adult tissues and its inactivation does not affect DNA methylation.
- Dnmt3 family members (Dnmt3a, Dnmt3b) are highly expressed in embryonic stem cells but downregulated during differentiation and in adult somatic tissues.
Mutations in the Dnmt3b gene are associated with ICF syndrome (Immunodeficiency, Centromeric instability, and Facial anomalies), a rare autosomal recessive disorder.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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