Thermo Fisher Scientific DNMT3A Polyclonal Antibody

Applications and Tested Dilution

Product Specifications

Product Specific Information

This antibody is predicted to react with chicken, mouse, and rat based on sequence homology.

Target Information

Methylation of DNA at cytosine residues plays an important role in gene expression regulation, genomic imprinting, and mammalian development. Aberrant methylation patterns, such as hypermethylation of tumor suppressor genes or hypomethylation of genomic DNA, are associated with cancer development. Three families of mammalian DNA methyltransferases have been identified: Dnmt1, Dnmt2, and Dnmt3.

• Dnmt1 is constitutively expressed in proliferating cells; its inactivation leads to global genomic demethylation and embryonic lethality.
• Dnmt2 is expressed at low levels in adult tissues and its inactivation does not affect DNA methylation.
• Dnmt3 family members (Dnmt3a, Dnmt3b) are highly expressed in embryonic stem cells but downregulated during differentiation and in adult somatic tissues.
  Mutations in the Dnmt3b gene are associated with ICF syndrome (Immunodeficiency, Centromeric instability, and Facial anomalies), a rare autosomal recessive disorder.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.