Thermo Fisher Scientific NALP1 Polyclonal Antibody

Applications

• Immunocytochemistry (ICC/IF): 0.25–2 µg/mL

Product Specifications

Product Specific Information

Immunogen sequence:
CVWDQFLGEI NPQHSWMVAG PLLDIKAEPG AVEAVHLPHF VALQGGHVDT SLFQMAHFKE EGMLLEKPAR VELHHIVLEN PSFSPLGVLL KMIHNALRFI PVTSVVLLYH RVHPEEVTFH LYLIPSDCSI RK

Target Information

NALP1 is a member of the Ced-4 family of apoptosis proteins. Ced-family members contain a caspase recruitment domain (CARD) and are known to be key mediators of programmed cell death. The encoded protein contains a distinct N-terminal pyrin-like motif, which is possibly involved in protein-protein interactions. This protein interacts strongly with caspase 2 and weakly with caspase 9. Overexpression of this gene was demonstrated to induce apoptosis in cells. Multiple alternatively spliced transcript variants encoding distinct isoforms have been found for this gene, but the biological validity of some variants has not been determined.

For Research Use Only.
Not for use in diagnostic procedures. Not for resale without express authorization.