Thermo Fisher Scientific DC-SIGN (CD209) Polyclonal Antibody

Applications and Tested Dilutions

Product Specifications

Product Specific Information

Reconstitute with 0.2 mL of distilled water to yield a concentration of 500 µg/mL.

Target Information

This gene encodes a transmembrane receptor often referred to as DC-SIGN due to its expression on the surface of dendritic cells and macrophages. The encoded protein plays an important role in the innate immune system, recognizing various pathogens including parasites and viruses.
The protein consists of three domains:

• N-terminal transmembrane domain
• Tandem-repeat neck domain
• C-type lectin carbohydrate recognition domain

The extracellular region (neck and lectin domains) functions as both a pathogen recognition receptor and a cell adhesion receptor by binding carbohydrate ligands on microbial and endogenous cell surfaces. The neck region mediates homo-oligomerization, enhancing multivalent ligand binding. Variations in the neck domain repeat number affect ligand-binding ability.

DC-SIGN is closely related to L-SIGN (GeneID 10332) but differs in ligand-binding properties and tissue distribution. Alternative splicing generates multiple variants.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.