Thermo Fisher Scientific EAAC1 Recombinant Rabbit Monoclonal Antibody (JU39-69)

Applications and Tested Dilutions

Product Specifications

Product Specific Information

Positive Control: Mouse liver tissue lysate, HUVEC, LOVO, SH-SY5Y, rat brain tissue, human tonsil tissue, human colon cancer tissue, human kidney tissue.
Localization: Cell membrane.

Target Information

L-glutamate is the major excitatory neurotransmitter in mammalian central nervous systems. To maintain glutamate levels below excitotoxic levels, excess glutamate at excitatory synaptic clefts is removed by ion-coupled glutamate transporters. Four glutamate transporters have been identified: the sodium-dependent GLAST-1, GLT-1, EAAC-1, and the chloride-dependent EAAT-4.

EAAC-1 is expressed in the CNS and also found in kidney and small intestine. Structural features of glutamate transporters include eight membrane-spanning alpha-helices and a loop-pore structure unique among secondary transporters but resembling loop-pores found in ion channels. A second distinctive feature is a highly amphipathic membrane-spanning helix that provides a hydrophilic path through the membrane.

Mice with homozygous deletions of the EAAC-1 transporter gene develop dicarboxylic aminoaciduria and display reduced spontaneous locomotor activity, although no neurodegeneration was observed over a period of 12 months.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.