Thermo Fisher Scientific HSD11B2 Polyclonal Antibody
Rabbit polyclonal antibody targeting human HSD11B2, validated for WB, IHC(P), and Flow Cytometry. Recognizes amino acids 277–306 of HSD11B2. Supplied as liquid, 0.5 mg/mL, purified by Protein A and antigen affinity. Ideal for research use in cortisol/c...
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Applications
| Application | Tested Dilution |
|---|---|
| Western Blot (WB) | 1:1,000 |
| Immunohistochemistry (Paraffin) (IHC (P)) | 1:50–1:100 |
| Flow Cytometry (Flow) | 1:10–1:50 |
Product Specifications
| Specification | Description |
|---|---|
| Species Reactivity | Human |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | KLH-conjugated synthetic peptide between 277–306 amino acids from the central region of human HSD11B2 |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 0.5 mg/mL |
| Purification | Protein A, Antigen affinity chromatography |
| Storage Buffer | PBS, pH 7.4 |
| Contains | 0.09% sodium azide |
| Storage Conditions | Store at 4°C (short term). For long-term storage, store at -20°C, avoiding freeze/thaw cycles. |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
| RRID | AB_2544267 |
Target Information
There are at least two isozymes of corticosteroid 11-beta-dehydrogenase, a microsomal enzyme complex responsible for the interconversion of cortisol and cortisone.
The type I isozyme has both 11-beta-dehydrogenase (cortisol to cortisone) and 11-oxoreductase (cortisone to cortisol) activities.
The type II isozyme, encoded by this gene, has only 11-beta-dehydrogenase activity.
In aldosterone-selective epithelial tissues such as the kidney, the type II isozyme catalyzes the conversion of cortisol to the inactive metabolite cortisone, preventing activation of the mineralocorticoid receptor.
In tissues lacking mineralocorticoid receptor expression, such as the placenta and testis, it protects cells from cortisol’s growth-inhibiting and pro-apoptotic effects, particularly during embryonic development.
Mutations in this gene cause apparent mineralocorticoid excess syndrome and hypertension.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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