Thermo Fisher Scientific QKI Polyclonal Antibody

Applications

Immunohistochemistry (IHC)

• Tested Dilution: 1:100–1:500

Immunohistochemistry (Paraffin) (IHC (P))

• Tested Dilution: 1:100–1:500

Product Specifications

Product Specific Information

• Recommended shelf life: 1 year from date of receipt
• Based on 100% sequence identity, predicted to react with Rat, Zebrafish, X. laevis, Chicken, Bovine, Dog, Horse, Pig, Cat, Orangutan, Monkey, Gorilla, and Chimpanzee

Target Information

This gene encodes the sacsin protein, which includes a UbL domain at the N-terminus, a DnaJ domain, and a HEPN domain at the C-terminus. It is highly expressed in the central nervous system, also found in skin, skeletal muscles, and at low levels in the pancreas. The gene includes a very large exon spanning more than 12.8 kb. Mutations result in autosomal recessive spastic ataxia of Charlevoix-Saguenay (ARSACS), characterized by early-onset cerebellar ataxia with spasticity and peripheral neuropathy. Sacsin protects against mutant ataxin-1. A pseudogene associated with this gene is located on chromosome 11. Alternative splicing results in multiple transcript variants.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.

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