Thermo Fisher Scientific Menin Polyclonal Antibody

Applications and Tested Dilution

Product Specifications

Product Specific Information

• 권장 유효기간: 수령일로부터 1년
• 100% 서열 동일성 기준으로 다음 종과 반응할 것으로 예측됨: Rat, Bovine, Dog, Horse, Guinea pig, Pig, Panda, Orangutan, Monkey, Gorilla, Chimpanzee, Dusky titi monkey

Target Information

Potassium channels are a group of ubiquitously expressed proteins that serve numerous functions in excitable and non-excitable cells. One class of integral membrane potassium channels is the large conductance, calcium-activated potassium channel (Maxi K+). Maxi K+ differs from most other potassium channels in that its activation is controlled by both increases in intracellular calcium and by membrane depolarization.

Maxi K+ dual activation is possible because of its structure. The core of the channel, which is similar to other potassium channels, is a Maxi K+ alpha homotetramer that contains both a voltage sensor and an intracellular calcium binding domain. In vascular smooth muscle, an auxiliary beta-subunit is found in a 1:1 stoichiometry. The beta-subunit exhibits its effect on the Maxi K+ channel by effectively decreasing by 5- to 10-fold the concentration of calcium required to keep the pore open.

For Research Use Only.
Not for use in diagnostic procedures.
Not for resale without express authorization.