Thermo Fisher Scientific CFTR (Cystic Fibrosis Transmembrane Conductance Regulator) Recombinant Rabbit Monoclonal Antibody (CFTR, 1775R)
CFTR 단백질을 표적으로 하는 Thermo Fisher의 재조합 토끼 단클론 항체. 인간 시료에 반응하며 IHC(P)에서 1–2 µg/mL 농도로 사용 가능. 단백질 A로 정제된 액상 항체로, 보존제 무첨가. CFTR 관련 연구 및 낭포성 섬유증 연구에 적합.
- 카탈로그번호
- 1080-RBM5-P1ABX
- 판매단위
- pk
카탈로그
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Applications and Tested Dilution
| Application | Tested Dilution |
|---|---|
| Immunohistochemistry (Paraffin) (IHC (P)) | 1–2 µg/mL |
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human |
| Host / Isotype | Rabbit / IgG |
| Expression System | HEK293 cells |
| Class | Recombinant Monoclonal |
| Type | Antibody |
| Clone | CFTR, 1775R |
| Immunogen | Recombinant fragment (around aa 258–385) of human CFTR protein |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Purification | Protein A |
| Storage Buffer | PBS, pH 7.4 |
| Contains | No preservative |
| Storage Conditions | –20°C or –80°C if preferred |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
Product Specific Information
- IHC (PFA fixed): Incubate antibody for 30 minutes at room temperature.
- Formalin-fixed tissues: Heat tissue sections in 10 mM Tris with 1 mM EDTA (pH 9.0) for 45 minutes at 95°C, then cool at room temperature for 20 minutes.
Target Information
Cystic Fibrosis (CF) is a common lethal genetic disease caused by mutations in the gene encoding the cystic fibrosis transmembrane conductance regulator (CFTR), a cAMP-regulated chloride channel. Approximately 70% of CF cases involve deletion of phenylalanine at position 508 (ΔF508), leading to abnormal chloride transport.
Despite its lethality, the persistence of this mutation may be linked to resistance against Salmonella typhi, as studies show ΔF508 heterozygote and homozygote mice exhibit 86% and 100% reductions in S. typhi intestinal uptake, respectively.
For Research Use Only.
Not for use in diagnostic procedures.
Not for resale without express authorization.
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