Thermo Fisher Scientific CFTR (Cystic Fibrosis Transmembrane Conductance Regulator) Recombinant Rabbit Monoclonal Antibody (CFTR, 1775R)

Applications and Tested Dilution

Product Specifications

Product Specific Information

• IHC (PFA fixed): Incubate antibody for 30 minutes at room temperature.
• Formalin-fixed tissues: Heat tissue sections in 10 mM Tris with 1 mM EDTA (pH 9.0) for 45 minutes at 95°C, then cool at room temperature for 20 minutes.

Target Information

Cystic Fibrosis (CF) is a common lethal genetic disease caused by mutations in the gene encoding the cystic fibrosis transmembrane conductance regulator (CFTR), a cAMP-regulated chloride channel. Approximately 70% of CF cases involve deletion of phenylalanine at position 508 (ΔF508), leading to abnormal chloride transport.
Despite its lethality, the persistence of this mutation may be linked to resistance against Salmonella typhi, as studies show ΔF508 heterozygote and homozygote mice exhibit 86% and 100% reductions in S. typhi intestinal uptake, respectively.

For Research Use Only.
Not for use in diagnostic procedures.
Not for resale without express authorization.