Thermo Fisher Scientific CNTNAP2 Polyclonal Antibody

Applications and Tested Dilutions

Product Specifications

Product Specific Information

• Reconstitute in 100 µL of sterile water.
• Centrifuge to remove any insoluble material.
• Specificity: CNTNAP2.

Target Information

The CNTNAP2 gene encodes a member of the neurexin family functioning in the vertebrate nervous system as cell adhesion molecules and receptors. This protein contains epidermal growth factor repeats, laminin G domains, F5/8 type C domain, discoidin/neuropilin- and fibrinogen-like domains, thrombospondin N-terminal-like domains, and a putative PDZ binding site.
It is localized at the juxtaparanodes of myelinated axons, mediating neuron-glia interactions during nervous system development and involved in potassium channel localization within differentiating axons.
CNTNAP2 spans almost 1.5% of chromosome 7, one of the largest human genes, and is regulated by FOXP2, a transcription factor related to speech and language development.
Mutations or dysregulation of this gene have been implicated in various neurodevelopmental disorders, including Gilles de la Tourette syndrome, schizophrenia, epilepsy, autism, ADHD, and mental retardation.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.