Thermo Fisher Scientific Nicotinic acetylcholine R alpha-10 Polyclonal Antibody
Rabbit polyclonal antibody against human nicotinic acetylcholine receptor alpha-10 subunit. Suitable for WB and IHC applications. Lyophilized form with no preservative. High species homology (85% to mouse and rat). For research use only.
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Applications
Western Blot (WB)
- Tested Dilution: 1:300–1:2,000
Immunohistochemistry (IHC)
- Tested Dilution: 1:300–1:2,000
Miscellaneous PubMed (Misc)
- Publications: 1 available
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human |
| Published Species | Not Applicable |
| Host / Isotype | Rabbit / Ig |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | Synthetic peptide from C-terminal region of human Neuronal acetylcholine receptor subunit alpha-10 conjugated to blue carrier protein |
| Conjugate | Unconjugated |
| Form | Lyophilized |
| Concentration | Not Determined |
| Storage Buffer | Whole serum |
| Contains | No preservative |
| Storage Conditions | Store at 4°C short term; for long term, store at -20°C avoiding freeze/thaw cycles. Glycerol (1:1) may be added for stability. |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
Product Specific Information
- Reconstitute in 100 µL of sterile water and centrifuge to remove insoluble material.
- Antigen shares 85% identity with mouse and rat sequences.
- Specificity: CHRNA10.
Target Information
Ionotropic receptor involved in modulation of auditory stimuli. Agonist binding induces conformational changes leading to opening of an ion channel permeable to divalent cations, including calcium. Calcium influx may activate potassium currents and hyperpolarize the cell membrane. In the ear, this process may reduce basilar membrane motion, modulate auditory nerve activity, and help protect against acoustic trauma.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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