Thermo Fisher Scientific NMDAR2B Polyclonal Antibody

Applications and Tested Dilution

Product Specifications

Product Specific Information

This antibody is predicted to react with bovine, canine, chicken, human, mouse, and non-human primate based on 100% sequence homology.

Target Information

NMDAR2B is a member of the N-methyl-D-aspartate (NMDA) class of ionotropic glutamate receptors. NMDA receptors (NMDAR) are involved in long-term potentiation, an activity-dependent increase in the efficiency of synaptic transmission thought to underlie memory and learning processes.

NMDARs play a role in neuronal development and have been implicated in several central nervous system disorders such as Alzheimer’s disease, epilepsy, and ischemic neuronal cell death. Overexpression of the NR2B subunit is associated with enhanced learning and memory, whereas reduced NR2B expression is observed in aged or memory-impaired animals.

Phosphorylation at Tyr1472 on NR2B may increase NMDAR expression at the synapse, contributing to synaptic plasticity. NMDAR2B forms a heterotrimer composed of seven genetically encoded and differentially expressed subunits, including NR1, NR2, and NR3. Dysfunction of NMDAR2B is associated with epileptic encephalopathy and autosomal dominant mental retardation.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.

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