ELK Biotechnology PAKα/β/γ (phospho Thr423/402/421) rabbit pAb
PAKα/β/γ 인산화(Thr423/402/421) 부위를 인식하는 rabbit polyclonal antibody. WB, IHC, IF, ELISA에 사용 가능. 세포골격 재구성과 핵 신호전달 연구에 적합. Human, Mouse, Rat 반응성.
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제품명
PAKα/β/γ (phospho Thr423/402/421) rabbit pAb
제품 정보
| 항목 | 내용 |
|---|---|
| Alternative Names | PAK1; Serine/threonine-protein kinase PAK1; Alpha-PAK; p21-activated kinase 1; PAK-1; p65-PAK; PAK2; Serine/threonine-protein kinase PAK2; Gamma-PAK; PAK65; S6/H4 kinase; p21-activated kinase 2; PAK-2; p58; PAK3; OPHN3; Serine/threonine-protein kinase PAK3 |
| Applications | WB; IHC; IF; ELISA |
| Recommended Dilutions | Western Blot: 1/500–1/2000 Immunohistochemistry: 1/100–1/300 ELISA: 1/5000 Not yet tested in other applications |
| Immunogen | Synthesized peptide derived from human PAK1/2/3 around the phosphorylation site of Thr423/402/421 (AA range: 391–440) |
| Host | Rabbit |
| Storage | -20°C, 1 year |
| Clonality | Polyclonal |
| Isotype | IgG |
| Concentration | 1 mg/ml |
| Observed Band | 60 kD |
| Gene ID (Human) | 5058 / 5062 / 5063 |
| Human Swiss-Prot No. | Q13153 / Q13177 / O75914 |
| Species Reactivity | Human; Mouse; Rat |
세포 내 위치
Cytoplasm, cell junction (focal adhesion), cell projection (lamellipodium, ruffle membrane, invadopodium), cell membrane, nucleus (nucleoplasm, chromosome), cytoskeleton (centrosome).
Colocalizes with RUFY3, F-actin, and other core migration components in invadopodia at the cell periphery (PubMed:25766321).
Recruited to the cell membrane by interaction with CDC42 and RAC1, and to focal adhesions upon activation.
Colocalized with CIB1 within membrane ruffles during cell spreading upon readhesion to fibronectin.
Upon DNA damage, translocates to the nucleoplasm when phosphorylated at Thr-212, co-recruited with MORC2 on damaged chromatin (PubMed:23260667).
Localization to the centrosome does not depend on phosphorylation.
Background
This gene encodes a member of the serine/threonine p21-activated kinase (PAK) family. PAK proteins are critical effectors linking Rho GTPases to cytoskeleton reorganization and nuclear signaling. They serve as targets for small GTP-binding proteins Cdc42 and Rac, regulating cell motility and morphology. Alternatively spliced transcript variants encoding different isoforms have been identified.
[Provided by RefSeq, Apr 2010]
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