ELK Biotechnology LEF-1 (phospho Ser42) rabbit pAb
인산화 Ser42 부위를 인식하는 LEF-1 rabbit polyclonal antibody로, Wnt 신호전달 관련 연구에 적합. WB 및 IHC에 사용 가능하며, 사람·생쥐·랫트 반응성. 핵 내 위치 단백질 검출에 유용. -20°C에서 1년 보관 가능.
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제품명
LEF-1 (phospho Ser42) rabbit pAb
공급업체
ELK Biotechnology
제품 정보
| 항목 | 내용 |
|---|---|
| Alternative Names | LEF1; Lymphoid enhancer-binding factor 1; LEF-1; T cell-specific transcription factor 1-alpha; TCF1-alpha |
| Applications | WB; IHC |
| Recommended Dilutions | WB 1:500–2000; IHC-p 1:50–300 |
| Immunogen | Synthesized peptide derived from human LEF-1 around the phosphorylation site of Ser42 (AA range: 8–57) |
| Host | Rabbit |
| Storage | -20°C / 1 year |
| Clonality | Polyclonal |
| Isotype | IgG |
| Concentration | 1 mg/ml |
| Observed Band | 55 kD |
| GeneID (Human) | 51176 |
| Human Swiss-Prot No | Q9UJU2 |
| Cellular Localization | Nucleus. Found in nuclear bodies upon PIASG binding. |
| Species Reactivity | Human; Mouse; Rat |
Background
This gene encodes a transcription factor belonging to a family of proteins that share homology with the high mobility group protein-1. The protein encoded by this gene can bind to a functionally important site in the T-cell receptor-alpha enhancer, thereby conferring maximal enhancer activity. This transcription factor is involved in the Wnt signaling pathway, and it may function in hair cell differentiation and follicle morphogenesis. Mutations in this gene have been found in somatic sebaceous tumors. This gene has also been linked to other cancers, including androgen-independent prostate cancer. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Oct 2009]
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