ELK Biotechnology Trk A (phospho Tyr701) rabbit pAb

제품명

Trk A (phospho Tyr701) rabbit pAb

제품 개요

본 항체는 인간 Trk A 단백질의 Tyr701 인산화 부위를 기반으로 제작된 rabbit polyclonal antibody입니다. 다양한 응용(WB, IHC, IF, ELISA)에 적합하며, 세포막 및 엔도솜에 위치한 Trk A 단백질의 검출에 활용됩니다.

제품 정보

세포 내 위치

Cell membrane; Single-pass type I membrane protein.
Early endosome membrane; Single-pass type I membrane protein.
Late endosome membrane; Single-pass type I membrane protein.
Recycling endosome membrane; Single-pass type I membrane protein.
Rapidly internalized after NGF binding (PubMed:1281417).
Internalized to endosomes upon NGF or NTF3 binding and transported to the cell body via retrograde axonal transport.
Localized at cell membrane and early endosomes before NGF stimulation; recruited to late endosomes after NGF stimulation; colocalized with RAPGEF2 at late endosomes.

Background

This gene encodes a member of the neurotrophic tyrosine kinase receptor (NTKR) family. This kinase is a membrane-bound receptor that, upon neurotrophin binding, phosphorylates itself and members of the MAPK pathway. The presence of this kinase leads to cell differentiation and may play a role in specifying sensory neuron subtypes. Mutations in this gene have been associated with congenital insensitivity to pain, anhidrosis, self-mutilating behavior, mental retardation, and cancer. Alternate transcriptional splice variants of this gene have been found, but only three have been characterized to date. [provided by RefSeq, Jul 2008]