Thermo Fisher Scientific DC-SIGN Recombinant Rabbit Monoclonal Antibody (ARC1679)
DC-SIGN 단백질을 인식하는 Thermo Fisher의 재조합 토끼 단클론 항체. Western blot, IHC, ICC/IF, ELISA에 적합하며 인간, 마우스, 랫트 시료에 반응. 고순도 Affinity Chromatography 정제, 2 mg/mL 농도의 액상 형태로 제공.
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Applications and Tested Dilutions
| Application | Tested Dilution |
|---|---|
| Western Blot (WB) | 1:500–1:2,000 |
| Immunohistochemistry (Paraffin) (IHC (P)) | 1:100–1:1,000 |
| Immunocytochemistry (ICC/IF) | 1:100–1:400 |
| ELISA | 1 µg/mL |
Product Specifications
| Specification | Detail |
|---|---|
| Species Reactivity | Human, Mouse, Rat |
| Host / Isotype | Rabbit / IgG |
| Expression System | HEK293 cells |
| Class | Recombinant Monoclonal |
| Type | Antibody |
| Clone | ARC1679 |
| Immunogen | A synthetic peptide corresponding to a sequence within amino acids 1–100 of human CD209 (Q9NNX6) |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 2 mg/mL |
| Purification | Affinity Chromatography |
| Storage Buffer | PBS, pH 7.3, with 50% glycerol, 0.05% BSA |
| Contains | 0.02% sodium azide |
| Storage Conditions | –20°C, Avoid Freeze/Thaw Cycles |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
| RRID | AB_2849728 |
Product Specific Information
Immunogen sequence:
MSDSKEPRLQ QLGLLEEEQL RGLGFRQTRG YKSLAGCLGH GPLVLQLLSF TLLAGLLVQV SKVPSSISQE QSRQDAIYQN LTQLKAAVGE LSEKSKLQEI
Target Information
This gene encodes a transmembrane receptor commonly referred to as DC-SIGN, expressed on the surface of dendritic cells and macrophages. It plays a critical role in the innate immune system by recognizing a wide range of pathogens, including parasites and viruses.
The protein has three main domains:
- N-terminal transmembrane domain
- Tandem-repeat neck domain
- C-type lectin carbohydrate recognition domain
The extracellular region (neck + lectin domains) functions both as a pathogen recognition receptor and a cell adhesion receptor, binding carbohydrate ligands on microbial and host cell surfaces. The neck region mediates homo-oligomerization, enhancing multivalent ligand binding. Variations in the 23-amino-acid repeats within this region can affect binding affinity.
DC-SIGN is closely related to L-SIGN (GeneID 10332), sharing sequence and functional similarities but differing in ligand specificity and tissue distribution. Alternative splicing leads to multiple isoforms.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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