Thermo Fisher Scientific SIRT5 Recombinant Rabbit Monoclonal Antibody (2U8A2)

Applications

Tested Dilution

Publications

Western Blot (WB)

1:1,000-1:5,000

-

ELISA (ELISA)

1 µg/mL

-

Product Specifications

Species Reactivity

Human, Mouse, Rat

Host/Isotype

Rabbit / IgG

Expression System

HEK293 cells

Class

Recombinant Monoclonal

Type

Antibody

Clone

2U8A2

Immunogen

Recombinant fusion protein containing a sequence corresponding to amino acids 37-310 of human SIRT5. if (typeof window.$mangular === undefined || !window.$mangular) { window.$mangular = {}; } $mangular.antigenJson = \[{targetFamily:SIRT5,uniProtId:Q9NXA8-1,ncbiNodeId:9606,antigenRange:37-310,antigenLength:310,antigenImageFileName:MA5-55336_SIRT5_Q9NXA8-1_Rabbit.svg,antigenImageFileNamePDP:MA5-55336_SIRT5_Q9NXA8-1_Rabbit_PDP.jpeg,sortOrder:1}\]; $mangular.isB2BCMGT = false; $mangular.isEpitopesModalImageMultiSizeEnabled = true;

View immunogen .st0{fill:#FFFFFF;} .st1{fill:#1E8AE7;}

Conjugate

Unconjugated Unconjugated Unconjugated

Form

Liquid

Concentration

1.89 mg/mL

Purification

Protein A

Storage buffer

PBS, pH 7.3, with 50% glycerol, 0.05% BSA

Contains

0.05% ProClin 300

Storage conditions

-20° C, Avoid Freeze/Thaw Cycles

Product Specific Information

Immunogen Sequence: SSSMADFRKF FAKAKHIVII SGAGVSAESG VPTFRGAGGY WRKWQAQDLA TPLAFAHNPS RVWEFYHYRR EVMGSKEPNA GHRAIAECET RLGKQGRRVV VITQNIDELH RKAGTKNLLE IHGSLFKTRC TSCGVVAENY KSPICPALSG KGAPEPGTQD ASIPVEKLPR CEEAGCGGLL RPHVVWFGEN LDPAILEEVD RELAHCDLCL VVGTSSVVYP AAMFAPQVAA RGVPVAEFNT ETTPATNRFR FHFQGPCGTT LPEALACHEN ETVS

Target Information

SIRT5 is a human member of a family of proteins called Sirtuins (Sir2-like proteins) and are present in prokaryotes and eukaryotes. All Sir2-like proteins have a sirtuin core domain, which contains a series of sequence motifs conserved in organisms ranging from bacteria to humans. Bacterial, yeast and mammalian sirtuins are able to metabolize NAD and possibly at as mono-ADP-ribosyltransferases. The enzymatic function of sirtuins is not yet completely understood but recent reports of histone-activated Sir2-mediated NAD metabolism and NAD-activated Sir2-mediated histone deacetylation suggest a possible coupled reciprocal activation mechanism involving interactions of Sir2 with NAD and the N epsilon-acetyl-lysine groups of acetylated histones.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.