Thermo Fisher Scientific HAX1 Polyclonal Antibody

Applications and Tested Dilutions

Product Specifications

Product Specific Information

• Store vial at -20°C prior to opening.
• Aliquot contents and freeze at -20°C or below for extended storage.
• Avoid repeated freeze/thaw cycles.
• Centrifuge product if not completely clear after standing at room temperature.
• Stable for several weeks at 4°C as an undiluted liquid.
• Dilute only prior to immediate use.
• Anti-HAX1 was affinity purified from monospecific antiserum by immunoaffinity chromatography.
• BLAST analysis suggests cross-reactivity with human, rat, and mouse based on 100% sequence homology.
• Cross-reactivity with HAX1 from other sources has not been determined.

Target Information

The HAX1 gene encodes a protein associated with hematopoietic cell-specific Lyn substrate 1, a substrate of Src family tyrosine kinases. It interacts with the polycystic kidney disease 2 gene product and the F-actin-binding protein cortactin. Initially thought to be localized in mitochondria, it is now known to localize in the cell body. Mutations in this gene cause autosomal recessive severe congenital neutropenia (Kostmann disease). Two transcript variants encoding different isoforms have been identified.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.