Thermo Fisher Scientific RGR Polyclonal Antibody

Applications

• Immunocytochemistry (ICC/IF)
  Tested Dilution: 0.25–2 µg/mL

Product Specifications

Product Specific Information

• Immunogen sequence: SLMEQKLGKS GHLQVNTTLP AR
• Antigen sequence identity: Mouse 68%; Rat 77%

Target Information

This gene encodes a putative retinal G-protein coupled receptor, a member of the opsin subfamily of the 7 transmembrane, G-protein coupled receptor 1 family. Like other opsins that bind retinaldehyde, it contains a conserved lysine residue in the seventh transmembrane domain. The protein functions as a photoisomerase catalyzing the conversion of all-trans-retinal to 11-cis-retinal, complementing rhodopsin’s reverse isomerization in retinal photoreceptor cells. Expression is localized to tissues adjacent to retinal photoreceptor cells, including the retinal pigment epithelium and Müller cells. This gene may be associated with autosomal recessive and autosomal dominant retinitis pigmentosa (arRP and adRP). Alternative splicing results in multiple transcript variants encoding different isoforms.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.