Thermo Fisher Scientific PDI Polyclonal Antibody

Applications

Product Specifications

Product Specific Information

• Positive Control: 293T, A431, H1299, HeLaS3, HepG2, Molt-4, Raji, mouse liver
• Predicted Reactivity: Rat (92%), Rabbit (91%), Chicken (83%), Chimpanzee (100%), Bovine (93%)
• Store product as a concentrated solution. Centrifuge briefly prior to opening the vial.

Target Information

Protein disulfide isomerase (PDI) is a multifunctional protein that catalyzes the formation, breakage, and rearrangement of disulfide bonds.
At the cell surface, it acts as a reductase that cleaves disulfide bonds of proteins attached to the cell, potentially causing structural modifications of exofacial proteins.
Inside the cell, PDI forms or rearranges disulfide bonds of nascent proteins. At high concentrations, it functions as a chaperone that inhibits aggregation of misfolded proteins; at low concentrations, it facilitates aggregation (anti-chaperone activity).
PDI may participate with other chaperones in structural modification of the TG precursor in hormone biogenesis.
It also acts as a structural subunit of various enzymes such as prolyl 4-hydroxylase and microsomal triacylglycerol transfer protein (MTTP).
Serves as a receptor for LGALS9, retaining P4HB at the cell surface of Th2 T helper cells, increasing disulfide reductase activity at the plasma membrane, altering redox state, and enhancing cell migration.

⚠ WARNING: This product can expose you to chemicals including mercury, known to the State of California to cause birth defects or other reproductive harm.
For more information, visit www.P65Warnings.ca.gov.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.