Thermo Fisher Scientific RHD Polyclonal Antibody

Applications and Tested Dilution

Product Specifications

Product Specific Information

Immunogen sequence:
LGNLRMVISN IFNTDYHMNM MHIYVFAAYF GLSVAWCLPK PLPEGTEDKD QTATIPSLSA MLGALFLWMF WPSFNSALLR SPIERKNAVF NTYYAVAVSV V

Positive Samples: U-251MG, LO2, rat spleen, rat liver
Cellular Location: Membrane, Multi-pass membrane protein

Target Information

The Rhesus (Rh) blood group system is one of the most complex and clinically important systems in humans. Two highly homologous genes, RHD and RHCE (collectively known as RH30 or RHCED), encode the antigens of this system. These genes are located on human chromosome 1p34.1–1p36.

The RHD gene encodes the D antigen, the most immunogenic Rh antigen, which is frequently deleted in Rh-negative individuals. Rh incompatibility between maternal and fetal blood types can cause hemolytic disease of the newborn (HDN).

The RHCE gene exists in four allelic forms, determining expression of Ce, ce, cE, or CE antigens. RHCED proteins are integral membrane proteins with 12 transmembrane helices, essential for erythrocyte membrane integrity. Functional Rh antigen presentation requires a complex with RHAG (RH50).

Safety Information

⚠ WARNING: This product can expose you to chemicals including mercury, which is known to the State of California to cause birth defects or other reproductive harm.
For more information, visit www.P65Warnings.ca.gov.

For Research Use Only.
Not for use in diagnostic procedures.
Not for resale without express authorization.