Thermo Fisher Scientific RHD Polyclonal Antibody
RHD 단백질을 인식하는 Rabbit Polyclonal 항체로 Western blot 및 ELISA에 적합. Human과 Rat 시료 반응성. 고순도 Affinity Chromatography 정제. PBS/glycerol buffer로 안정화되어 -20°C에서 보관. 연구용으로만 사용.
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Applications and Tested Dilution
| Application | Tested Dilution |
|---|---|
| Western Blot (WB) | 1:500–1:2,000 |
| ELISA | 1 µg/mL |
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human, Rat |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | Synthetic peptide corresponding to amino acids 150–250 of human RHD (NP_001121163.1) |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 2.4 mg/mL |
| Purification | Affinity Chromatography |
| Storage Buffer | PBS, pH 7.3, with 50% glycerol |
| Contains | 0.01% thimerosal |
| Storage Conditions | -20°C, Avoid Freeze/Thaw Cycles |
| Shipping Conditions | Wet ice |
| RRID | AB_2805964 |
Product Specific Information
Immunogen sequence:
LGNLRMVISN IFNTDYHMNM MHIYVFAAYF GLSVAWCLPK PLPEGTEDKD QTATIPSLSA MLGALFLWMF WPSFNSALLR SPIERKNAVF NTYYAVAVSV V
Positive Samples: U-251MG, LO2, rat spleen, rat liver
Cellular Location: Membrane, Multi-pass membrane protein
Target Information
The Rhesus (Rh) blood group system is one of the most complex and clinically important systems in humans. Two highly homologous genes, RHD and RHCE (collectively known as RH30 or RHCED), encode the antigens of this system. These genes are located on human chromosome 1p34.1–1p36.
The RHD gene encodes the D antigen, the most immunogenic Rh antigen, which is frequently deleted in Rh-negative individuals. Rh incompatibility between maternal and fetal blood types can cause hemolytic disease of the newborn (HDN).
The RHCE gene exists in four allelic forms, determining expression of Ce, ce, cE, or CE antigens. RHCED proteins are integral membrane proteins with 12 transmembrane helices, essential for erythrocyte membrane integrity. Functional Rh antigen presentation requires a complex with RHAG (RH50).
Safety Information
⚠ WARNING: This product can expose you to chemicals including mercury, which is known to the State of California to cause birth defects or other reproductive harm.
For more information, visit www.P65Warnings.ca.gov.
For Research Use Only.
Not for use in diagnostic procedures.
Not for resale without express authorization.
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